{"id":"W4380836596","doi":"10.1161/circ.146.suppl_1.15469","title":"Abstract 15469: Activation of Sting Pathway Promotes Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Wall","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Aortic aneurysm repair treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kimberly-Clark (Canada)","funders":"","keywords":"Epigenetics; Chromatin; Biology; Chromatin remodeling; Cell biology; Phenotypic switching; Proinflammatory cytokine; Chromatin immunoprecipitation; Phenotype; Medicine; Cancer research; Gene expression; Immunology; Gene; Inflammation; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001650313,0.0003447995,0.000344574,0.0002880871,0.0003043648,0.0003556518,0.0001614696,0.0003253573,0.007468203],"category_scores_gemma":[0.0001332026,0.000183293,0.0003757927,0.0002059917,0.0002416525,0.0001994884,0.0003062822,0.0008885349,0.001501529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000264948,"about_ca_system_score_gemma":0.0002598805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005181662,"about_ca_topic_score_gemma":0.0009272909,"domain_scores_codex":[0.9997777,0.00002075953,0.00001529883,0.00007389995,0.00006493824,0.00004743866],"domain_scores_gemma":[0.9998838,0.00001299839,0.00003732802,0.00001314715,0.00001801404,0.00003481305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001956474,0.00002011886,0.0005516995,0.0001231898,0.00001270257,0.00006553966,0.00002260519,0.00003914642,0.9967679,0.00007318774,0.0003275039,0.001800748],"study_design_scores_gemma":[0.00009468418,0.000766532,0.0788323,0.00007307407,0.0001090462,0.0007646136,0.0001681477,0.001765835,0.9008768,0.0002444126,0.01627907,0.00002547532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762498,0.004380691,0.006044751,0.0003999113,0.0003265522,0.00004970362,0.008235225,0.0004522104,0.003861223],"genre_scores_gemma":[0.9791917,0.001858483,0.002749345,0.0004000044,0.00008079243,0.00008035429,0.007940493,0.0001045579,0.007594417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007468203,"threshold_uncertainty_score":0.02498358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02643169859253929,"score_gpt":0.2595922262498113,"score_spread":0.233160527657272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}