{"id":"W4380853678","doi":"10.1038/s41380-023-02095-y","title":"A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression","year":2023,"lang":"en","type":"letter","venue":"Molecular Psychiatry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Mental Health; Allergan; Substance Abuse and Mental Health Services Administration; Janssen Research and Development; Victoria General Hospital Foundation; Servier; Innovative Medicines Initiative; National Center for Advancing Translational Sciences; Medical Research Council; Department of Health and Social Care; National Institute for Health and Care Research; Instituto D'Or de Pesquisa e Ensino; Maudsley Charity; Academy of Medical Sciences; Psychiatry Research Trust; King's College London; Neurocrine Biosciences; NIHR Maudsley Biomedical Research Centre; Sanofi; GW Pharmaceuticals; South London and Maudsley NHS Foundation Trust; Canadian Institutes of Health Research; Jazz Pharmaceuticals; Wellcome Trust; Michael Smith Health Research BC; H. Lundbeck A/S; Sunovion; European Federation of Pharmaceutical Industries and Associations; National Institutes of Health; Rosetrees Trust; European Commission; Eli Lilly and Company; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Alliance for Research on Schizophrenia and Depression; GlaxoSmithKline; LivaNova; Pfizer","keywords":"Serotonergic; Serotonin; Depression (economics); Psychology; Neuroscience; Value (mathematics); Cognitive psychology; Psychiatry; Medicine; Computer science; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008761984,0.0009938016,0.002251153,0.00126243,0.002441423,0.003738125,0.003038781,0.0323374,0.003722331],"category_scores_gemma":[0.04814857,0.0006829053,0.001699909,0.001067008,0.00539269,0.007958165,0.001531815,0.0340372,0.007137479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004296551,"about_ca_system_score_gemma":0.002925937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002591303,"about_ca_topic_score_gemma":0.003706888,"domain_scores_codex":[0.9938553,0.001804493,0.001404576,0.0008744353,0.00176821,0.0002929357],"domain_scores_gemma":[0.970319,0.01852071,0.001957317,0.001000021,0.00646434,0.001738555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000128161,0.00003168689,0.0002512739,0.0004126106,0.00004152467,0.001380895,0.000106962,0.00004887243,0.0003582914,0.002899357,0.9685302,0.02581023],"study_design_scores_gemma":[0.0001306185,0.0001276028,0.001201972,0.001230747,0.00008439711,0.004688,0.0004067268,0.0003895329,0.0004669512,0.02120166,0.9699794,0.00009244888],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002004188,0.007561886,0.0001869928,0.9245127,0.06675008,0.000007959963,0.00004459502,0.00003565639,0.0006996223],"genre_scores_gemma":[0.002035586,0.006524079,0.0003340333,0.8834116,0.1056268,0.00002376813,0.00002369304,0.00002516964,0.001995302],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0323374,"threshold_uncertainty_score":0.04633838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05726980484423946,"score_gpt":0.3072800565495131,"score_spread":0.2500102517052737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}