{"id":"W4380867888","doi":"10.1161/circ.146.suppl_1.15203","title":"Abstract 15203: Single Cell Transcriptional Analysis Implicates <i>Acta2</i> Positive Pericytes in Arterial Muscularization and Imbalance in Bmp and Angpt Signaling During Development of Pulmonary Arterial Hypertension","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Public Health","funders":"","keywords":"Medicine; Downregulation and upregulation; Pericyte; BMPR2; Arteriogenesis; Pulmonary hypertension; Noggin; Matricellular protein; Cancer research; Pathology; Internal medicine; Endocrinology; Angiogenesis; Cell biology; Endothelial stem cell; Biology; Extracellular matrix; Bone morphogenetic protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632203,0.0003108214,0.000347532,0.0003271742,0.0003744342,0.0003791365,0.0001689544,0.0002893925,0.006366013],"category_scores_gemma":[0.0001230329,0.0001449219,0.0003044658,0.0003354,0.0002457846,0.0001346624,0.0001666353,0.0005896574,0.002248011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002164683,"about_ca_system_score_gemma":0.0002345331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001212631,"about_ca_topic_score_gemma":0.002296038,"domain_scores_codex":[0.9997442,0.00001700066,0.00001996538,0.00008143954,0.00009028955,0.00004691913],"domain_scores_gemma":[0.9998474,0.0000208873,0.00004057632,0.00001577321,0.00002654491,0.00004881182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008005757,0.00001226458,0.0005741257,0.00003108806,0.000005679111,0.00007692345,0.0000179011,0.00001603662,0.9980474,0.00003247987,0.0003008348,0.0008051425],"study_design_scores_gemma":[0.0000314602,0.0003396711,0.1333156,0.00002252263,0.00005421138,0.001563629,0.0001820059,0.001849747,0.8533506,0.00009608303,0.009176128,0.00001842955],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637369,0.0009721476,0.01171757,0.0004652737,0.0001831162,0.00006182868,0.01695844,0.0007874816,0.005117291],"genre_scores_gemma":[0.9397926,0.0008425748,0.01331305,0.0004993935,0.0000787641,0.0001791927,0.02584142,0.0003131423,0.01913975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006366013,"threshold_uncertainty_score":0.02129644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01756041191304893,"score_gpt":0.2329536007624152,"score_spread":0.2153931888493663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}