{"id":"W4380869582","doi":"10.1097/j.pain.0000000000002956","title":"Evolving acidic microenvironments during colitis provide selective analgesic targets for a pH-sensitive opioid","year":2023,"lang":"en","type":"article","venue":"Pain","topic":"Anesthesia and Pain Management","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; National Institutes of Health; Crohn's and Colitis Canada; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"Pharmacology; Nociception; Analgesic; Colitis; Nociceptor; Inflammation; Opioid; Chemistry; Fentanyl; Anesthesia; Infiltration (HVAC); Medicine; Internal medicine; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001410191,0.000162814,0.0002470206,0.0001554022,0.0001740801,0.00001750223,0.00005891991,0.00005414776,0.00003814371],"category_scores_gemma":[0.0004047887,0.0001612404,0.0001077367,0.0002547733,0.00005924873,0.00005505156,0.00003353312,0.00009906483,0.0001290473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002075645,"about_ca_system_score_gemma":0.00003673517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004869448,"about_ca_topic_score_gemma":0.00001146512,"domain_scores_codex":[0.998566,0.0002558575,0.0001823592,0.0003509323,0.0001930056,0.0004518811],"domain_scores_gemma":[0.9992429,0.0003624795,0.00006805024,0.0001771245,0.00003824782,0.0001112048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002721987,0.0007793126,0.6033143,0.004952332,0.002020236,0.003115611,0.01695671,0.0002049069,0.1745315,0.000656505,0.1483477,0.042399],"study_design_scores_gemma":[0.002143904,0.0004513542,0.937422,0.0003395415,0.0001968259,0.00002950135,0.002432511,0.009695216,0.02508441,0.000545564,0.02130334,0.0003558667],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732305,0.0003671129,0.01697583,0.003716832,0.00007484729,0.004121209,0.00001534502,0.0004235505,0.001074699],"genre_scores_gemma":[0.9908808,0.00006140663,0.001180251,0.001626111,0.0001589419,0.0002937292,0.00008699346,0.00004326439,0.005668452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3341077,"threshold_uncertainty_score":0.6575195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009966531466684575,"score_gpt":0.2351536626817096,"score_spread":0.225187131215025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}