{"id":"W4380869582","doi":"10.1097/j.pain.0000000000002956","title":"Evolving acidic microenvironments during colitis provide selective analgesic targets for a pH-sensitive opioid","year":2023,"lang":"en","type":"article","venue":"Pain","topic":"Anesthesia and Pain Management","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; National Institutes of Health; Crohn's and Colitis Canada; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"Pharmacology; Nociception; Analgesic; Colitis; Nociceptor; Inflammation; Opioid; Chemistry; Fentanyl; Anesthesia; Infiltration (HVAC); Medicine; Internal medicine; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007943745,0.0001778463,0.0001995015,0.00007861492,0.00008821102,0.0001860664,0.00008934423,0.0002300937,0.001037308],"category_scores_gemma":[0.00008128017,0.00008771996,0.0001345495,0.00005840478,0.0001324331,0.0002372705,0.0001312961,0.0003149639,0.0001376708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001162872,"about_ca_system_score_gemma":0.00009564457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001992828,"about_ca_topic_score_gemma":0.0002957797,"domain_scores_codex":[0.9999518,0.000005533705,0.000002932858,0.000008652378,0.000009805047,0.00002125512],"domain_scores_gemma":[0.9999583,0.000005949375,0.00001550493,0.000004429995,0.00000548964,0.00001035688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000307656,0.00001221828,0.0001584588,0.00001910984,0.000001751662,0.00002054216,0.000004126086,0.00002518564,0.9987406,0.00001202849,0.00001034484,0.0006879643],"study_design_scores_gemma":[0.00004411575,0.001725566,0.01914071,0.00001057773,0.00002135272,0.0003554985,0.00004467665,0.000973053,0.9766715,0.00003787379,0.0009700273,0.000005149315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964031,0.001669087,0.001352495,0.00005033015,0.00001253971,0.00001954504,0.00009646551,0.000019855,0.0003765567],"genre_scores_gemma":[0.9975855,0.0007317757,0.001042902,0.00004087886,0.000009495538,0.00001617511,0.0001089011,0.000004391687,0.0004600072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001037308,"threshold_uncertainty_score":0.003470123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009966531466684575,"score_gpt":0.2351536626817096,"score_spread":0.225187131215025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}