{"id":"W4380871083","doi":"10.1038/s41590-023-01528-8","title":"SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity","year":2023,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"National Institute on Aging; University of California, San Diego; U.S. Department of Health and Human Services; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Cure Alzheimer's Fund; JPB Foundation","keywords":"Enhancer; Microglia; SMAD; Transcription factor; Cell biology; Biology; Regulation of gene expression; Gene; Genetics; Transforming growth factor; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462289,0.0001320206,0.0001644979,0.0001726572,0.00007945283,0.00002385001,0.0001834956,0.0006500605,0.00001550165],"category_scores_gemma":[0.00004363036,0.0001182289,0.00006918349,0.0003583392,0.0001194433,0.000009909458,0.0001693288,0.0003139043,0.0000320699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000185999,"about_ca_system_score_gemma":0.00003382223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002073978,"about_ca_topic_score_gemma":0.00002729432,"domain_scores_codex":[0.9991316,0.00003754596,0.0001851044,0.0003138283,0.00008252965,0.0002494409],"domain_scores_gemma":[0.9995602,0.00001417305,0.00008062783,0.0002177292,0.00008662358,0.0000406605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002122786,0.000009884291,0.0006466935,0.00001857813,0.0001406496,0.000003947102,0.00006235065,0.000008954907,0.9860825,0.0002794805,0.006830901,0.00570381],"study_design_scores_gemma":[0.0004722,0.0003134018,0.01016442,0.00003078775,0.00002379355,0.00002391118,0.0001790665,0.000001546553,0.7954027,0.0001470636,0.1930791,0.0001619441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878147,0.01008918,0.00006245836,0.0002713628,0.00122802,0.0001188411,0.00002598671,0.00002863229,0.0003607832],"genre_scores_gemma":[0.9941653,0.003307168,0.0001022687,0.0001645793,0.0001366412,0.000009360554,0.0001488214,0.00001792044,0.001947921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1906797,"threshold_uncertainty_score":0.5013862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00501842729304708,"score_gpt":0.2359777456114349,"score_spread":0.2309593183183879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}