{"id":"W4380871083","doi":"10.1038/s41590-023-01528-8","title":"SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity","year":2023,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"National Institute on Aging; University of California, San Diego; U.S. Department of Health and Human Services; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Cure Alzheimer's Fund; JPB Foundation","keywords":"Enhancer; Microglia; SMAD; Transcription factor; Cell biology; Biology; Regulation of gene expression; Gene; Genetics; Transforming growth factor; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872985,0.0003264264,0.0001980726,0.0003864221,0.0002522117,0.0002898349,0.0002430759,0.0002550195,0.002330147],"category_scores_gemma":[0.0001300999,0.0002741066,0.0002821653,0.00009650077,0.0003477956,0.0001629159,0.0004822219,0.0007351331,0.0007326151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004756641,"about_ca_system_score_gemma":0.0003520669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000596129,"about_ca_topic_score_gemma":0.001840765,"domain_scores_codex":[0.9997684,0.00003216775,0.0000149063,0.00004871357,0.00006184532,0.00007391821],"domain_scores_gemma":[0.999734,0.00003329023,0.000103813,0.00002980679,0.00001962276,0.0000794724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003786837,0.000006504733,0.0001596581,0.00001161278,0.000001312044,0.00002147816,0.000006630795,0.00003488146,0.9992301,0.0001007875,0.00001483095,0.0003742557],"study_design_scores_gemma":[0.000007202885,0.00004894674,0.002792582,0.000004414867,0.000004761747,0.0001397532,0.00002310218,0.0005736226,0.9947034,0.00004662529,0.001652675,0.000002938894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907218,0.00108649,0.005165218,0.0001687463,0.00002784355,0.0000177396,0.0003925994,0.0001811416,0.002238443],"genre_scores_gemma":[0.994404,0.0002897134,0.002127717,0.00006906418,0.00000775541,0.00001589309,0.0003696339,0.0000437749,0.002672591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002330147,"threshold_uncertainty_score":0.007795155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00501842729304708,"score_gpt":0.2359777456114349,"score_spread":0.2309593183183879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}