{"id":"W4380872223","doi":"10.1093/nar/gkad520","title":"Chromatin opening ability of pioneer factor Pax7 depends on unique isoform and C-terminal domain","year":2023,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Compute Canada","keywords":"Chromatin; Biology; Gene isoform; Enhancer; Transcription factor; DNA; Cell biology; Genetics; Pioneer factor; Chromatin remodeling; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009672141,0.0001645833,0.0001392035,0.0001040346,0.00009204917,0.0002222828,0.000140923,0.0001464939,0.001216943],"category_scores_gemma":[0.0001308723,0.00009810342,0.0001614142,0.00005415756,0.0002696894,0.0001783136,0.0002480704,0.0003789181,0.0003226761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001583063,"about_ca_system_score_gemma":0.0001379242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003622242,"about_ca_topic_score_gemma":0.0007486952,"domain_scores_codex":[0.9999113,0.00001134831,0.000005622196,0.00002395319,0.00002821417,0.00001951106],"domain_scores_gemma":[0.9998527,0.00004633336,0.0000260698,0.00002132072,0.00001163052,0.00004193682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001859726,0.000002057737,0.0001593796,0.000004039326,7.958024e-7,0.00001369706,0.000002754066,0.000012294,0.9995242,0.00004015102,0.000002217657,0.0002198094],"study_design_scores_gemma":[0.000006121893,0.00006340021,0.009963103,0.00000260662,0.000005890399,0.0002752081,0.00002052212,0.0005899754,0.9881725,0.00006302879,0.0008332545,0.000004355531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976155,0.0003604435,0.00117218,0.00001727285,0.000003712268,0.000003454095,0.00005693186,0.00001787758,0.0007527387],"genre_scores_gemma":[0.9980806,0.0001367151,0.0007832043,0.00001457545,0.000002236053,0.000005721796,0.0002078358,0.00001469083,0.000754481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216943,"threshold_uncertainty_score":0.004071116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03111284509599044,"score_gpt":0.3312965217084435,"score_spread":0.300183676612453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}