{"id":"W4380872654","doi":"10.1021/jacs.3c03512","title":"Teraryl Braces in Macrocycles: Synthesis and Conformational Landscape Remodeling of Peptides","year":2023,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Higher Education Discipline Innovation Project; Nankai University; National Natural Science Foundation of China","keywords":"Chemistry; Heteroatom; Aryl; Side chain; Cyclic peptide; Peptide; Combinatorial chemistry; Stereochemistry; Organic chemistry; Biochemistry; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067615,0.0002847489,0.0001562292,0.0001809113,0.0001467559,0.0002669315,0.0002060956,0.0001949945,0.001172823],"category_scores_gemma":[0.0001546198,0.0001666243,0.0001291336,0.0001494861,0.0002286298,0.0003102929,0.0003474029,0.0004267736,0.0004836798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001593237,"about_ca_system_score_gemma":0.0001207059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001699306,"about_ca_topic_score_gemma":0.0005133284,"domain_scores_codex":[0.999935,0.000008033664,0.000005774342,0.00001858591,0.00001260179,0.0000199827],"domain_scores_gemma":[0.9999514,0.000007078071,0.00001381198,0.00000765955,0.000005093672,0.00001489201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007733834,0.00004078956,0.000119428,0.0001469284,0.0000102778,0.0002140649,0.0001055864,0.0009531396,0.9760583,0.005467841,0.0003550653,0.01645133],"study_design_scores_gemma":[0.00006563831,0.0007889705,0.0009924062,0.00002895257,0.00001745214,0.0002671608,0.00003932817,0.002724988,0.9619644,0.0009879165,0.03209314,0.00002970203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9316267,0.008930326,0.03497235,0.000316204,0.0002303503,0.0002040246,0.0003347779,0.0006574118,0.02272792],"genre_scores_gemma":[0.9805239,0.00392377,0.01033795,0.0001524173,0.00003082793,0.0001662875,0.0001360134,0.00008629226,0.004642406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001172823,"threshold_uncertainty_score":0.003923416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00695365776102429,"score_gpt":0.2387021346853616,"score_spread":0.2317484769243373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}