{"id":"W4380877329","doi":"10.1002/alz.061902","title":"ELUCIDATING THE COMBINED EFFECTS OF AMYLOID AND TAU IN A NOVEL BIGENIC RAT MODEL WITH HUMAN ALZHEIMER’S DISEASE‐LIKE PATHOLOGY","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Genetically modified mouse; Context (archaeology); Pathology; Amyloid (mycology); Alzheimer's disease; Medicine; Dementia; Amyloid precursor protein; Neuroscience; Disease; Psychology; Transgene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004716572,0.001380339,0.000547074,0.001275482,0.0003661299,0.0003594807,0.0004670448,0.0006541287,0.001695817],"category_scores_gemma":[0.0001544339,0.0003672146,0.0005246081,0.0002755146,0.0005407095,0.0004877804,0.0004886213,0.0008944806,0.0003610343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004676402,"about_ca_system_score_gemma":0.0003334195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001299029,"about_ca_topic_score_gemma":0.003178716,"domain_scores_codex":[0.9996673,0.00004915035,0.00003360243,0.0001099565,0.00006555839,0.00007445037],"domain_scores_gemma":[0.999498,0.00003917555,0.0001702017,0.0000661166,0.00004886685,0.0001776907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006106796,0.0003748673,0.0006191699,0.00003018756,0.00001599431,0.000209941,0.00003765849,0.00003715103,0.9968013,0.0001252439,0.00005239065,0.001085449],"study_design_scores_gemma":[0.0002416413,0.01474317,0.03318023,0.00004432584,0.0002470317,0.003793963,0.000273428,0.001744931,0.9417699,0.000399961,0.003504018,0.00005756769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959658,0.0003759294,0.002395846,0.00009186762,0.00003457902,0.00007289831,0.0003573499,0.000115738,0.000589932],"genre_scores_gemma":[0.984587,0.0006275882,0.008849906,0.0001228964,0.00002523254,0.0001850249,0.0007758061,0.00005019683,0.004776418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001695817,"threshold_uncertainty_score":0.005673051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03381373398369281,"score_gpt":0.3048369266262858,"score_spread":0.2710231926425929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}