{"id":"W4380877347","doi":"10.1002/alz.065334","title":"Degradation of CNTNAP2 is mediated by both macroautophagy‐lysosome pathway and ubiquitin‐proteasome pathway","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Lysosome; Proteasome; Cell biology; Immunoprecipitation; LAMP1; Ubiquitin; Biology; HEK 293 cells; Colocalization; Protein degradation; Autophagy; Transfection; Chemistry; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043343,0.0004134667,0.0002615245,0.0001940967,0.0002571977,0.0003574442,0.0001091295,0.0001903571,0.001107608],"category_scores_gemma":[0.0001109788,0.00008523345,0.0002550298,0.0001003187,0.0001530394,0.0003594571,0.0001624669,0.0001955824,0.0002557376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000420565,"about_ca_system_score_gemma":0.0002246516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001108089,"about_ca_topic_score_gemma":0.001483326,"domain_scores_codex":[0.9999042,0.00001065704,0.000008356753,0.00003053161,0.00002577244,0.00002052447],"domain_scores_gemma":[0.999926,0.000008644047,0.00002067155,0.000006778336,0.00001791114,0.00002008832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001853573,0.00002040072,0.002523715,0.0001149836,0.00002834375,0.0007742526,0.00001901092,0.00006834965,0.9924447,0.0002225669,0.000177685,0.00342064],"study_design_scores_gemma":[0.00003826732,0.0004877293,0.08079622,0.0000303603,0.00009089958,0.006621785,0.0001078376,0.003105867,0.8967564,0.0005481606,0.01139309,0.00002333862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707237,0.01888273,0.005655434,0.0001995234,0.00007854639,0.0000374116,0.0005672111,0.00009576482,0.003759624],"genre_scores_gemma":[0.9908876,0.003944823,0.001949023,0.00005433557,0.0000301111,0.00002822591,0.0004760725,0.000009163454,0.002620726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108089,"threshold_uncertainty_score":0.003705323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0281099613735395,"score_gpt":0.2870067654794318,"score_spread":0.2588968041058923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}