{"id":"W4380877375","doi":"10.1002/alz.064015","title":"Aggregation and antibody‐based inhibition of TDP‐43","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trent University","funders":"","keywords":"Thioflavin; Antibody; Fibril; Protein aggregation; Chemistry; Western blot; In vitro; Molecular biology; Phosphorylation; Biochemistry; Biophysics; Biology; Medicine; Pathology; Disease; Alzheimer's disease; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002305096,0.0004177899,0.0002738501,0.0002074018,0.0001713025,0.0001655017,0.0002314511,0.0003237904,0.0005145472],"category_scores_gemma":[0.0001325063,0.0001424422,0.0002962648,0.000154311,0.0001217144,0.00009782346,0.000129251,0.0004587435,0.0002206554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003562554,"about_ca_system_score_gemma":0.0001498967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009747949,"about_ca_topic_score_gemma":0.0009513606,"domain_scores_codex":[0.9998158,0.00003809071,0.00001713147,0.00004112111,0.00004629826,0.00004159644],"domain_scores_gemma":[0.9999233,0.00001788037,0.0000158822,0.000009542394,0.00002085039,0.00001253927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007871121,0.00006945008,0.00003483541,0.00002803402,0.000006134301,0.0000230187,0.000008500519,0.00009255097,0.9987889,0.0000357499,0.00005437212,0.0007797012],"study_design_scores_gemma":[0.00002262947,0.0007747398,0.001446477,0.000003642795,0.00001849781,0.000104363,0.000003488699,0.001589471,0.9948968,0.00001473095,0.001122546,0.000002597337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884838,0.003523394,0.005740196,0.00008243966,0.00009238193,0.00007976925,0.0001881402,0.0001458168,0.001663915],"genre_scores_gemma":[0.9927647,0.001144733,0.003388852,0.00009160422,0.00002248818,0.00007250043,0.0003182844,0.00001949492,0.002177418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009747949,"threshold_uncertainty_score":0.002584815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04739438999176166,"score_gpt":0.3327072984808266,"score_spread":0.2853129084890649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}