{"id":"W4380878181","doi":"10.1016/b978-0-12-824315-2.00672-2","title":"Stress (health) toxicology: Pollutant exposure and the hypothalamic-pituitary-adrenal (HPA) axis","year":2023,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Health Canada","funders":"","keywords":"Endocrine system; Chronic stress; Hypothalamic–pituitary–adrenal axis; Medicine; Immune system; Disease; Endocrinology; Neuroscience; Internal medicine; Psychology; Immunology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001210624,0.0006500624,0.0003589267,0.0005668323,0.0003890306,0.001615688,0.0003418275,0.001134957,0.0241059],"category_scores_gemma":[0.0001297253,0.000160615,0.0001888714,0.0009189161,0.0006420256,0.001146902,0.0006835926,0.001079422,0.006100878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006233527,"about_ca_system_score_gemma":0.0006051112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003392736,"about_ca_topic_score_gemma":0.01045734,"domain_scores_codex":[0.9999459,0.000007847208,0.00000227322,0.000009639553,0.00002877109,0.000005628598],"domain_scores_gemma":[0.9999554,0.00002282665,0.000003614653,0.000001872695,0.000008584224,0.000007770273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001252929,0.000140529,0.0008535856,0.001227896,0.00002338812,0.0007364978,0.0006010756,0.0009036561,0.009871153,0.0607699,0.2373645,0.6873825],"study_design_scores_gemma":[0.000006405422,0.00008332583,0.002567107,0.0004605674,0.000009979318,0.0009966564,0.0002739556,0.0001983967,0.0007213909,0.02478847,0.9698822,0.00001166456],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.003000833,0.6255801,0.002827317,0.007144675,0.004348164,0.00002457048,0.0001798832,0.00009324279,0.3568013],"genre_scores_gemma":[0.01836997,0.43898,0.001826635,0.002656853,0.004158446,0.00003229245,0.0001190023,0.00003909265,0.5338178],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.0241059,"threshold_uncertainty_score":0.08064228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03002303212788455,"score_gpt":0.2600120458983166,"score_spread":0.2299890137704321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}