{"id":"W4380879920","doi":"10.1136/ard-2023-223859","title":"Tripterygium wilfordii derivative celastrol, a YAP inhibitor, has antifibrotic effects in systemic sclerosis","year":2023,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Robarts Clinical Trials; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Killam Trusts; Arthritis Society; School of Graduate Studies, Utah State University","keywords":"Celastrol; Fibrosis; CTGF; Medicine; Cancer research; Bleomycin; Dermal fibroblast; Transforming growth factor; Fibroblast; Pathology; Biology; Growth factor; Endocrinology; Internal medicine; Cell culture; Apoptosis; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009748031,0.000177427,0.0002630953,0.0003161878,0.0001786787,0.0001938953,0.0001463126,0.0002015296,0.001200206],"category_scores_gemma":[0.00008659803,0.00007643624,0.0002064298,0.0001504394,0.0001911796,0.0001966501,0.0001950667,0.0005066934,0.0001808627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001397182,"about_ca_system_score_gemma":0.0002236538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005341442,"about_ca_topic_score_gemma":0.0009075488,"domain_scores_codex":[0.9999503,0.000008066176,0.000005066898,0.000006579216,0.00001409976,0.00001587775],"domain_scores_gemma":[0.9999473,0.000009673919,0.00001019846,0.000004236795,0.000008051057,0.00002040105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002105649,0.0002012259,0.0004537834,0.0004126801,0.00004907579,0.000414466,0.00003662272,0.000295286,0.9713831,0.0002042293,0.0006711474,0.02377272],"study_design_scores_gemma":[0.0006418969,0.005303591,0.01293443,0.00002818999,0.000198006,0.001686588,0.00009267876,0.001127959,0.9568184,0.0001633861,0.02097494,0.000029876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717274,0.02278195,0.001178054,0.0003210949,0.000140795,0.00003135857,0.0002739792,0.0001261104,0.003419324],"genre_scores_gemma":[0.9907352,0.006231512,0.000606868,0.0001004145,0.00003462418,0.00002529123,0.0003170306,0.000007672277,0.001941389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200206,"threshold_uncertainty_score":0.004015088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07306366824157232,"score_gpt":0.2838972554380457,"score_spread":0.2108335871964734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}