{"id":"W4380884024","doi":"10.1002/alz.065616","title":"Effect of alpha‐Synuclein on the binding of [18F]MK‐6240 and [18F]AV‐1451","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill Genome Centre; Concordia University; McGill University Health Centre; Montreal Neurological Institute and Hospital; Douglas Mental Health University Institute; Douglas College; McGill University","funders":"","keywords":"Trypsinization; Chemistry; Ligand (biochemistry); Binding site; Biophysics; Serial dilution; Trypsin; Molecular biology; Biochemistry; Receptor; Biology; Pathology; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003993149,0.0004901455,0.0004238678,0.0002253373,0.0002816496,0.0004550873,0.0003868985,0.000401388,0.002186103],"category_scores_gemma":[0.0003626146,0.0003791461,0.0002399825,0.0002029198,0.000277257,0.0001777245,0.0002144015,0.0005832654,0.0007907859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005875217,"about_ca_system_score_gemma":0.0003620795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004414212,"about_ca_topic_score_gemma":0.006068603,"domain_scores_codex":[0.9995829,0.0001113219,0.00001756958,0.00008724213,0.00008600127,0.0001149151],"domain_scores_gemma":[0.9997049,0.0001258849,0.00003713109,0.0000212563,0.0000427359,0.00006793808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003435696,0.00003840907,0.0001012682,0.00004768312,0.00001254207,0.00004227296,0.00003514981,0.00009237138,0.9984758,0.00004726695,0.00006227373,0.0007014339],"study_design_scores_gemma":[0.00001460719,0.0004263343,0.004189763,0.000009705049,0.00001581989,0.0001312489,0.0000333581,0.001731612,0.9921314,0.00002756053,0.001280977,0.000007507337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919864,0.002484944,0.001832113,0.0000540852,0.0000309965,0.00003167308,0.0002626559,0.00007737504,0.003239801],"genre_scores_gemma":[0.989108,0.001220095,0.00351247,0.00007072759,0.0000113798,0.00004117937,0.0007585539,0.00007432121,0.005203268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004414212,"threshold_uncertainty_score":0.008777022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02530821119143594,"score_gpt":0.2902095696435087,"score_spread":0.2649013584520727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}