{"id":"W4380894068","doi":"10.1016/j.str.2023.05.015","title":"Mechanistic and structural insights into the bifunctional enzyme PaaY from Acinetobacter baumannii","year":2023,"lang":"en","type":"article","venue":"Structure","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Thioesterase; Acinetobacter baumannii; Biochemistry; Enzyme; Active site; Chemistry; Carbonic anhydrase; Hydrolase; Biology; Bacteria; Biosynthesis; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002181195,0.000539861,0.000303543,0.0001416574,0.0003554005,0.0005606202,0.0005166848,0.0005641295,0.0008840616],"category_scores_gemma":[0.0001742249,0.0001755627,0.0001857423,0.000171913,0.0004961513,0.0005206441,0.0002721147,0.00104417,0.0002370915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008420268,"about_ca_system_score_gemma":0.0006297697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001741979,"about_ca_topic_score_gemma":0.001323107,"domain_scores_codex":[0.999938,0.0000123657,0.000004466353,0.000009239233,0.00002000738,0.00001591746],"domain_scores_gemma":[0.9999571,0.000009270001,0.000009935675,0.000004365321,0.000006467191,0.00001294611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009199877,0.000196443,0.001813215,0.0003198403,0.00002618288,0.001459327,0.0002307895,0.01243494,0.9448541,0.02383844,0.0005834061,0.01332339],"study_design_scores_gemma":[0.0001239978,0.0008326997,0.004088046,0.00003660582,0.00005725869,0.002251817,0.0006032707,0.04335332,0.9243709,0.008014355,0.01620965,0.00005808467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780492,0.005299017,0.01009594,0.001487917,0.0001077328,0.000027143,0.0002722722,0.0001740976,0.004486645],"genre_scores_gemma":[0.9940612,0.00150653,0.00319442,0.0000802873,0.00001182735,0.000008853725,0.0002184321,0.000008681884,0.0009097873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001741979,"threshold_uncertainty_score":0.006109297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005695839482156797,"score_gpt":0.216248223981857,"score_spread":0.2105523844997002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}