{"id":"W4380894086","doi":"10.1002/alz.062258","title":"Biomarkers for the detection of progressive early Alzheimer’s Disease","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Montreal Cognitive Assessment; Internal medicine; Dementia; Biomarker; Atrophy; Medicine; Alzheimer's Disease Neuroimaging Initiative; Apolipoprotein E; Oncology; Cognitive decline; Alzheimer's disease; Neuroimaging; Cerebrospinal fluid; Psychology; Pathology; Disease; Psychiatry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002567619,0.00073351,0.0006299132,0.00200805,0.0002398238,0.001018722,0.0004381744,0.0007239046,0.001436481],"category_scores_gemma":[0.005717644,0.000329636,0.0003780855,0.0009119266,0.0002783747,0.0005396324,0.0002579991,0.0006947277,0.0006808988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003323941,"about_ca_system_score_gemma":0.0003825613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001244974,"about_ca_topic_score_gemma":0.001014985,"domain_scores_codex":[0.9990001,0.0004024217,0.0001004061,0.0002205441,0.0002151148,0.00006148863],"domain_scores_gemma":[0.9967028,0.001245191,0.0009549261,0.0001323397,0.0007204927,0.0002442151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003387628,0.0004647976,0.8775853,0.0004063691,0.0006161668,0.0002277642,0.00007631699,0.001004764,0.01630905,0.0003194932,0.002913135,0.09668928],"study_design_scores_gemma":[0.0003469651,0.002579939,0.9555476,0.0002712045,0.0006339416,0.002845498,0.0001551983,0.009476268,0.01753256,0.001696839,0.008828485,0.00008549883],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9339569,0.05143237,0.005709163,0.0008320673,0.0002557279,0.0001850621,0.002168948,0.0003079241,0.005151819],"genre_scores_gemma":[0.9839866,0.003292645,0.009646812,0.000340391,0.0001891597,0.0001299526,0.001001428,0.00001117653,0.001401787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002567619,"threshold_uncertainty_score":0.01357901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0429076433953253,"score_gpt":0.3376868582987643,"score_spread":0.294779214903439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}