{"id":"W4380986318","doi":"10.1016/s2352-3026(23)00118-7","title":"Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021","year":2023,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":666,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sistema Nacional de Investigadores; Warwick Medical School; National Health and Medical Research Council; Medical Research Council; Universidad Autónoma de Sinaloa; Secretaría Nacional de Ciencia, Tecnología e Innovación; Shahid Beheshti University of Medical Sciences; Universidad Nacional Autónoma de México; University of Jordan; Universitetet i Bergen; Jawaharlal Institute Of Postgraduate Medical Education and Research; Ahvaz Jundishapur University of Medical Sciences; Tehran University of Medical Sciences and Health Services; Sultan Qaboos University; Shiraz University of Medical Sciences; Shiraz University; Uniwersytet Łódzki; King Abdulaziz University; Manipal Academy of Higher Education; Isfahan University of Medical Sciences; Banaras Hindu University; Department of Sport and Recreation, Government of Western Australia; University of Sydney; Ministero della Salute; Southern Cross University; University Grants Commission; Indian Council of Medical Research; National Institute for Health and Care Research; Ministry of Health and Medical Education; University of Pretoria; Babol University of Medical Sciences; Cleveland Clinic; York University; Science and Technology Development Fund; University of Toronto; Macquarie University; Imperial College London; Philadelphia University; University of Technology Sydney; University of Warwick; Høgskulen på Vestlandet; University of Central Punjab; University of Aberdeen; Universidade de São Paulo; South Eastern Sydney Local Health District; Cleveland Clinic Foundation; Florida International University; Ain Shams University; King Abdulaziz City for Science and Technology; Academy of Scientific Research and Technology; Shaqra University; Tulane University; Iran University of Medical Sciences; Chandigarh University; Trường Đại học Duy Tân; Alfaisal University; Kasturba Medical College, Manipal; University of New South Wales; Yale University; Karolinska Institutet; Bill and Melinda Gates Foundation","keywords":"Medicine; Disease; Epidemiology; Population; Incidence (geometry); Disease burden; Mortality rate; Pediatrics; Acute chest syndrome; Sickle cell anemia; Demography; Environmental health; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009907521,0.0009912414,0.002720371,0.00863581,0.0002898647,0.0009270298,0.0007513021,0.0007932331,0.0009770887],"category_scores_gemma":[0.01552526,0.0008160189,0.009189009,0.01038326,0.0005342295,0.0006042447,0.001701844,0.0007192111,0.0002306201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001442623,"about_ca_system_score_gemma":0.00493517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03630338,"about_ca_topic_score_gemma":0.06451537,"domain_scores_codex":[0.9940976,0.002428601,0.001430014,0.0009402873,0.0008967113,0.0002068203],"domain_scores_gemma":[0.9912873,0.003087597,0.002748023,0.0006492312,0.00198127,0.0002465812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001898146,0.00006292534,0.5782081,0.1480298,0.1345316,0.0006548653,0.002006196,0.00436499,0.001097419,0.001227108,0.02637542,0.1015434],"study_design_scores_gemma":[0.0008806193,0.0003677688,0.7894903,0.04752217,0.1322353,0.001097174,0.0009345072,0.002516506,0.0005478977,0.001065513,0.0231413,0.0002009614],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1950886,0.7115671,0.004577773,0.002305691,0.0003107481,0.0006953803,0.08398405,0.0001588274,0.001311759],"genre_scores_gemma":[0.7122841,0.2433825,0.006662826,0.001550853,0.0002020032,0.001705565,0.03366122,0.00006660607,0.000484372],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03630338,"threshold_uncertainty_score":0.07218415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02636332678182835,"score_gpt":0.3061564235177414,"score_spread":0.2797930967359131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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