{"id":"W4380992446","doi":"10.3389/fcimb.2023.1202276","title":"A conserved epitope in VAR2CSA is targeted by a cross-reactive antibody originating from Plasmodium vivax Duffy binding protein","year":2023,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Malaria Research and Control","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Li Ka Shing Institute of Virology, University of Alberta; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation; National Institutes of Health; University of Alberta","keywords":"Epitope; Biology; Antibody; Virology; Plasmodium vivax; Monoclonal antibody; Antigenicity; Molecular biology; Plasmodium falciparum; Genetics; Immunology; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433443,0.0004623852,0.0002486102,0.0002525151,0.0001156088,0.0001385661,0.0002410891,0.0003361619,0.0008918152],"category_scores_gemma":[0.0001525593,0.0001598575,0.0002924005,0.0001849967,0.0001671303,0.0001030971,0.0001624865,0.0004649446,0.0002127064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003131635,"about_ca_system_score_gemma":0.0001249581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006352388,"about_ca_topic_score_gemma":0.00099712,"domain_scores_codex":[0.9998073,0.00003314075,0.00001494336,0.00004694509,0.00004557188,0.00005226386],"domain_scores_gemma":[0.9998736,0.00003011696,0.00003422144,0.00001201816,0.00001590437,0.00003412452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004103437,0.00002317339,0.0001975715,0.00001161604,0.000002832403,0.00003045196,0.000004475532,0.00003779644,0.9992398,0.00001344359,0.000007246127,0.0003906525],"study_design_scores_gemma":[0.00002023898,0.0008709129,0.009282715,0.000006614166,0.00002512247,0.0005803039,0.00002139396,0.001138177,0.9870286,0.00002580644,0.0009944012,0.000005702453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977455,0.0002404164,0.001530372,0.0000233751,0.000007083238,0.00001389942,0.00006856258,0.0000134879,0.0003573312],"genre_scores_gemma":[0.9963287,0.0001837102,0.002586904,0.00007521212,0.000005155702,0.0000148197,0.0003215495,0.000006924093,0.0004770576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008918152,"threshold_uncertainty_score":0.002983391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009289520032535678,"score_gpt":0.2764691026371805,"score_spread":0.2671795826046448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}