{"id":"W4380995267","doi":"10.1161/circ.146.suppl_1.13235","title":"Abstract 13235: Ischemic Preconditioning and Lazaroid (u-74389g) Administration Similarly Attenuate Ischemia-Reperfusion-Induced Spinal Cord Inflammatory and Apoptotic Responses by Targeting the S100-Receptor for Advanced Glycation End Product Pathway","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Neuroprotection; Anesthesia; Spinal cord; Ischemia; Paraplegia; Lumbar Spinal Cord; Inflammation; Reperfusion injury; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508734,0.0006545621,0.0006847333,0.0003158736,0.0002039669,0.0002019511,0.0003277574,0.0005014581,0.004789652],"category_scores_gemma":[0.0001035162,0.0001641797,0.0004326862,0.0001840153,0.0005007113,0.0003528482,0.0001904965,0.0009943802,0.0006180121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002046628,"about_ca_system_score_gemma":0.0006373625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006331616,"about_ca_topic_score_gemma":0.0009524398,"domain_scores_codex":[0.9998848,0.00001104533,0.00001190968,0.00002254383,0.00002009897,0.00004952536],"domain_scores_gemma":[0.999889,0.000006917647,0.00003173075,0.00001014173,0.00001212635,0.00005001311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01619618,0.00322741,0.0005449998,0.0004481941,0.00005722605,0.0002296693,0.00007014024,0.0001660781,0.9644295,0.0002165703,0.0006899529,0.01372402],"study_design_scores_gemma":[0.003234631,0.0926165,0.01515868,0.00009051057,0.0002147283,0.0005587003,0.0001575613,0.0009149176,0.8809123,0.0001914861,0.005922976,0.00002705461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953264,0.001607442,0.0006616825,0.0002050192,0.0001322027,0.0001652143,0.000469967,0.0001214401,0.001310574],"genre_scores_gemma":[0.9882545,0.002099495,0.001645359,0.0002393895,0.00008675242,0.0004118764,0.001268161,0.00001541939,0.005979002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004789652,"threshold_uncertainty_score":0.01602298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415400323618984,"score_gpt":0.2676167491006146,"score_spread":0.2534627458644247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}