{"id":"W4380997330","doi":"10.1161/circ.146.suppl_1.14950","title":"Abstract 14950: Single-Cell Transcriptomic Analysis Reveals Emergence of Inflammatory and Activated Arterial Endothelial Cells Promoted by Cross-Talk With Mural Cells During Development of Severe Pulmonary Arterial Hypertension","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Public Health","funders":"","keywords":"Medicine; Transcriptome; Proinflammatory cytokine; Pulmonary hypertension; Hypoxia (environmental); Internal medicine; Gene expression; Cardiology; Pathology; Inflammation; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001292895,0.0001946019,0.0003123468,0.0003366499,0.0001729744,0.0003059098,0.000111124,0.0002290754,0.002287726],"category_scores_gemma":[0.0001687319,0.00008904772,0.0002021285,0.0003242439,0.0001765656,0.0001180688,0.000195126,0.000352723,0.0004908052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000115912,"about_ca_system_score_gemma":0.000128352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003585918,"about_ca_topic_score_gemma":0.0005997167,"domain_scores_codex":[0.999853,0.00001064912,0.000008357027,0.00005035147,0.00004589851,0.00003170066],"domain_scores_gemma":[0.9998826,0.00001875412,0.00003201926,0.000008083987,0.00002364456,0.00003489299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001483734,0.00001162302,0.001981951,0.00003724698,0.00001099842,0.00008704681,0.00002941784,0.0000326209,0.9958691,0.00002508003,0.0001285171,0.001637946],"study_design_scores_gemma":[0.00002796251,0.0007240086,0.5577443,0.00002996808,0.0001067011,0.001478822,0.0003542682,0.003868635,0.4300725,0.0001836519,0.005385075,0.00002419882],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987802,0.0007598891,0.0048324,0.0000885768,0.00004788259,0.00002899776,0.00557056,0.0001121994,0.0007575299],"genre_scores_gemma":[0.9810717,0.0005868168,0.006328296,0.0001604428,0.00003324274,0.00009895697,0.008255512,0.00006101565,0.003404162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002287726,"threshold_uncertainty_score":0.007653177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01665400201146965,"score_gpt":0.2310382280245392,"score_spread":0.2143842260130696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}