{"id":"W4381033614","doi":"10.1016/j.scr.2023.103148","title":"Lymphoblastoid cell lines derived from iPSCs of a myotonic dystrophy type 1 patient carrying 700 CTG repeats (CBRCULi007-A) and a control (CBRCULi006-A)","year":2023,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Fonds de Recherche du Québec - Santé; U.S. Department of Defense","keywords":"Myotonic dystrophy; Biology; Induced pluripotent stem cell; Trinucleotide repeat expansion; Genetics; Karyotype; Gene; Germ layer; Myotonia; Lymphoblast; Molecular biology; Cell culture; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000399182,0.0003144555,0.0004413227,0.000532213,0.0004215985,0.0001345281,0.000534425,0.0001124897,0.00008095608],"category_scores_gemma":[0.0003724913,0.0002917123,0.0001240459,0.001354494,0.000476109,0.0001068397,0.000512088,0.0003327635,0.0002828681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009217083,"about_ca_system_score_gemma":0.0004182588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001611454,"about_ca_topic_score_gemma":0.00001685823,"domain_scores_codex":[0.9948226,0.001177091,0.0005196081,0.001169465,0.00141273,0.0008984701],"domain_scores_gemma":[0.996711,0.00145622,0.0001773912,0.0008042778,0.0004788277,0.0003723317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003136528,0.0001357457,0.001682023,0.0001415224,0.00001026482,0.0001400216,0.001091108,0.0005333262,0.9944052,0.00001248872,0.0003577739,0.001176928],"study_design_scores_gemma":[0.001358663,0.0006740307,0.003319182,0.00005830417,0.0000226832,0.000003046456,0.0008467687,0.002700279,0.990143,0.00008941083,0.0005411825,0.0002434185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960504,0.001026361,0.00002476915,0.0001268883,0.0002777175,0.001022776,0.0002610884,0.0001044388,0.001105526],"genre_scores_gemma":[0.9980803,0.0006075168,0.00006273167,0.00009873693,0.00008736076,0.0001171865,0.00001462774,0.00007426852,0.0008573175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004262114,"threshold_uncertainty_score":0.9999535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07023495559530313,"score_gpt":0.3108840906418945,"score_spread":0.2406491350465914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}