{"id":"W4381033614","doi":"10.1016/j.scr.2023.103148","title":"Lymphoblastoid cell lines derived from iPSCs of a myotonic dystrophy type 1 patient carrying 700 CTG repeats (CBRCULi007-A) and a control (CBRCULi006-A)","year":2023,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Fonds de Recherche du Québec - Santé; U.S. Department of Defense","keywords":"Myotonic dystrophy; Biology; Induced pluripotent stem cell; Trinucleotide repeat expansion; Genetics; Karyotype; Gene; Germ layer; Myotonia; Lymphoblast; Molecular biology; Cell culture; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002752852,0.0003473955,0.0003408824,0.0004563977,0.0002894149,0.0002933205,0.0003051356,0.0004418346,0.004166984],"category_scores_gemma":[0.0002838176,0.000122314,0.0003122887,0.000426256,0.0002068778,0.0001220364,0.0002618054,0.000863496,0.002593438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001660983,"about_ca_system_score_gemma":0.0002115365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000597595,"about_ca_topic_score_gemma":0.0007185247,"domain_scores_codex":[0.9997811,0.00003283964,0.00004661467,0.00004809525,0.00006353636,0.00002790527],"domain_scores_gemma":[0.9998358,0.00004713701,0.0000208688,0.00003400715,0.00002945283,0.0000327316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004568822,0.0001098145,0.001322866,0.00007935891,0.00001500629,0.001541617,0.0002605172,0.0001462179,0.9908293,0.0007317917,0.0005772611,0.00392927],"study_design_scores_gemma":[0.0002708156,0.0008002023,0.01205042,0.00005438578,0.0001361631,0.009020469,0.0002860448,0.002032456,0.9366522,0.0004520927,0.03819547,0.00004946308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9385057,0.001278589,0.03147988,0.0003031388,0.0003121494,0.0009985948,0.0114521,0.0004873188,0.01518254],"genre_scores_gemma":[0.932529,0.001527902,0.03021272,0.0002570276,0.00005970045,0.000813318,0.01975954,0.0001673313,0.01467338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004166984,"threshold_uncertainty_score":0.01393998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07023495559530313,"score_gpt":0.3108840906418945,"score_spread":0.2406491350465914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}