{"id":"W4381059948","doi":"10.1097/shk.0000000000002165","title":"INVESTIGATION OF THE PATHOLOGICAL EFFECTS OF HISTONES, DNA, AND NUCLEOSOMES IN A MURINE MODEL OF SEPSIS","year":2023,"lang":"en","type":"article","venue":"Shock","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Histone; Nucleosome; Neutrophil extracellular traps; In vivo; Cytotoxic T cell; Biology; Chemistry; Cell biology; In vitro; DNA; Molecular biology; Inflammation; Immunology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003827129,0.0007907128,0.0003650044,0.0004713538,0.0001915735,0.000221222,0.000281269,0.00070899,0.001069585],"category_scores_gemma":[0.0001076687,0.0002474053,0.0004343586,0.000155883,0.0003871315,0.0003025413,0.000212235,0.0009859904,0.0003077017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003126993,"about_ca_system_score_gemma":0.0002653143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002920965,"about_ca_topic_score_gemma":0.0004091911,"domain_scores_codex":[0.9997664,0.00004285796,0.00002618883,0.00005413307,0.0000595891,0.00005074765],"domain_scores_gemma":[0.999799,0.00002046595,0.00006349412,0.00002330972,0.00002354826,0.00007015436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006244644,0.0001926299,0.0003272828,0.00007385932,0.000008805092,0.0001007108,0.00001650007,0.0000962632,0.9977121,0.00006760082,0.00003963076,0.0007401473],"study_design_scores_gemma":[0.0001477117,0.008235421,0.008168465,0.00003671116,0.00006436193,0.0008678641,0.00007592292,0.00219846,0.9783392,0.000104218,0.001748486,0.00001310843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991192,0.002669821,0.004058675,0.0001800606,0.0001132101,0.0001091042,0.0004886913,0.0001035597,0.001084846],"genre_scores_gemma":[0.9901482,0.001860237,0.004305156,0.0001795125,0.00003246048,0.0001482782,0.0006648084,0.00001675307,0.002644549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001069585,"threshold_uncertainty_score":0.003578067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01883336110274564,"score_gpt":0.2178496840051969,"score_spread":0.1990163229024513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}