{"id":"W4381059948","doi":"10.1097/shk.0000000000002165","title":"INVESTIGATION OF THE PATHOLOGICAL EFFECTS OF HISTONES, DNA, AND NUCLEOSOMES IN A MURINE MODEL OF SEPSIS","year":2023,"lang":"en","type":"article","venue":"Shock","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Histone; Nucleosome; Neutrophil extracellular traps; In vivo; Cytotoxic T cell; Biology; Chemistry; Cell biology; In vitro; DNA; Molecular biology; Inflammation; Immunology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001172186,0.00007359724,0.0002239636,0.00008737394,0.00002239146,6.139265e-7,0.00009734349,0.00009952712,0.00001413468],"category_scores_gemma":[0.00006506116,0.00004898907,0.00004188835,0.0001998926,0.00023824,0.00002518477,0.0001113981,0.00008833126,0.000005886578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008344238,"about_ca_system_score_gemma":0.0000204347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002685937,"about_ca_topic_score_gemma":0.00001085336,"domain_scores_codex":[0.9994217,0.0001302795,0.0001963015,0.0001232208,0.00002618502,0.0001023848],"domain_scores_gemma":[0.9996175,0.000103667,0.00009879564,0.000145382,0.00002744321,0.000007208509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002867724,0.00001799246,0.003728925,0.00009784524,0.00001518501,0.000001554338,0.0006422229,0.00002352534,0.992566,0.00231895,0.000103034,0.0004560386],"study_design_scores_gemma":[0.0005210969,0.000118912,0.04920112,0.00007060201,0.00001623957,0.000002032657,0.00006474127,0.00007389899,0.9439383,0.005929142,0.00001835674,0.00004553954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991521,0.0003290689,0.00002988825,0.0001596453,0.00008607944,0.0001626744,0.0000167736,0.00001151554,0.00005229587],"genre_scores_gemma":[0.9994769,0.00007360206,0.000100744,0.00005295387,0.000002710883,0.000006830996,0.00000931078,0.000005392732,0.000271555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04862773,"threshold_uncertainty_score":0.1997716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01883336110274564,"score_gpt":0.2178496840051969,"score_spread":0.1990163229024513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}