{"id":"W4381089891","doi":"10.1093/narcan/zcad030","title":"DICER1 platform domain missense variants inhibit miRNA biogenesis and lead to tumor susceptibility","year":2023,"lang":"en","type":"article","venue":"NAR Cancer","topic":"Congenital Diaphragmatic Hernia Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Texas MD Anderson Cancer Center","keywords":"Missense mutation; Germline; microRNA; Biology; Genetics; Endoribonuclease; Ribonuclease III; Biogenesis; Somatic cell; Gene silencing; Cancer research; Gene; Mutation; RNase P; RNA interference; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001831733,0.0001960912,0.0001976437,0.0002877393,0.0001647615,0.0001554336,0.0001739658,0.0003525149,0.00218217],"category_scores_gemma":[0.0005948061,0.0001000839,0.0001510082,0.0001820554,0.0002022609,0.00007616681,0.0002420103,0.0002147867,0.0001717919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001295485,"about_ca_system_score_gemma":0.0001209426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003191245,"about_ca_topic_score_gemma":0.0004356831,"domain_scores_codex":[0.9998412,0.00004738172,0.0000225539,0.00003997398,0.00002896362,0.00001997084],"domain_scores_gemma":[0.9996374,0.0001438783,0.0001032139,0.00002951914,0.00002228391,0.0000637324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001351964,0.0001724852,0.08566866,0.0001797213,0.0001664417,0.006036489,0.0001621946,0.0004995827,0.8902987,0.0009211615,0.0006505545,0.01389193],"study_design_scores_gemma":[0.0001553199,0.001574555,0.4883128,0.00004810347,0.0002003782,0.0531817,0.0002396139,0.002809536,0.4453118,0.0005843671,0.007552853,0.00002903259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978259,0.0006510881,0.000505872,0.00004698455,0.000009542222,0.000008929174,0.0001803616,0.00001997302,0.0007512919],"genre_scores_gemma":[0.9990249,0.0001519761,0.0004051375,0.00001877624,0.000003758587,0.000003943114,0.0001120853,0.000004748943,0.0002746138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00218217,"threshold_uncertainty_score":0.007300019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03696688922843552,"score_gpt":0.3152014420412308,"score_spread":0.2782345528127953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}