{"id":"W4381093580","doi":"10.1101/2023.06.16.545367","title":"Dual effects of the small-conductance Ca <sup>2+</sup> -activated K <sup>+</sup> current on human atrial electrophysiology and Ca <sup>2+</sup> -driven arrhythmogenesis: an <i>in silico</i> study","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Afterdepolarization; Refractory period; Atrial fibrillation; Cardiac electrophysiology; Electrophysiology; Internal medicine; Effective refractory period; Atrial action potential; Cardiology; Chemistry; Reentry; Conductance; Atrial myocytes; Sinus rhythm; Intracellular; Myocyte; Beat (acoustics); Membrane potential; Medicine; Repolarization; Physics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001886477,0.0003081888,0.0004320304,0.0001755935,0.0001795189,0.0004225679,0.0005438068,0.0009579755,0.001533523],"category_scores_gemma":[0.0005109242,0.0001434664,0.0006976826,0.0001463964,0.0003422645,0.0003702351,0.0003283103,0.0003911682,0.000161974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002902275,"about_ca_system_score_gemma":0.0003170877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003140469,"about_ca_topic_score_gemma":0.001897018,"domain_scores_codex":[0.9999251,0.00001822792,0.000004599738,0.00001673837,0.00001894091,0.00001625944],"domain_scores_gemma":[0.9997328,0.0001564587,0.00003464862,0.00002460515,0.00003198896,0.00001947235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001422038,0.0001346007,0.002765479,0.0001213554,0.00005783894,0.0002941626,0.00006595652,0.9647998,0.02733243,0.00107491,0.0003133903,0.002897858],"study_design_scores_gemma":[0.00002009014,0.0001185446,0.001098529,0.000007510103,0.00002018917,0.00004343649,0.00002238863,0.9947323,0.003290496,0.000323216,0.0003138305,0.000009389052],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681903,0.0003411248,0.02418139,0.0003816356,0.00005607346,0.0000519563,0.0003983776,0.000144262,0.00625497],"genre_scores_gemma":[0.9979589,0.0001065074,0.001326126,0.00003911537,0.000004850551,0.0000207696,0.00006620853,0.00000780857,0.0004696861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003140469,"threshold_uncertainty_score":0.006244421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02248331844429476,"score_gpt":0.2633443881579382,"score_spread":0.2408610697136434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}