{"id":"W4381125350","doi":"10.1136/gutjnl-2023-bsg.370","title":"P304 Impact of mirikizumab on histologic measures of intestinal inflammation in a phase 2 study of patients with moderate-severe crohn’s disease","year":2023,"lang":"en","type":"article","venue":"Poster presentations","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Gastroenterology; Medicine; Crohn's disease; Ascending colon; Internal medicine; Clinical endpoint; Rectum; Ileum; Randomized controlled trial; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007381805,0.0001174677,0.0001463463,0.0001757961,0.00002646277,0.000005949686,0.0001149018,0.00003238504,0.00001384111],"category_scores_gemma":[0.0001913929,0.00009759278,0.00006400039,0.000174328,0.00006311713,0.00001393719,0.00005301887,0.00004439033,0.000002098042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002193588,"about_ca_system_score_gemma":0.0001396054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007493333,"about_ca_topic_score_gemma":0.0001491606,"domain_scores_codex":[0.9989934,0.0001386913,0.000338603,0.0001860749,0.0002219117,0.000121327],"domain_scores_gemma":[0.9991351,0.00002566792,0.0002073964,0.000280943,0.0002868091,0.00006409839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01168809,0.00186522,0.9602324,0.00009069051,0.0001087992,0.00004842979,0.001211277,0.0186185,0.00554802,0.000009321091,0.0001439365,0.0004353593],"study_design_scores_gemma":[0.004236981,0.0009552568,0.9913929,0.00002915725,0.00004585168,3.477535e-7,0.0002106545,0.0004475313,0.002550772,0.00003627196,0.000001192231,0.00009310289],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988872,0.000008861021,0.00004013512,0.000012091,0.00001844894,0.0007384223,0.0001889711,0.000007960032,0.00009788804],"genre_scores_gemma":[0.9994496,0.000001476969,0.00002279645,0.000004129922,0.000009972277,0.00007832433,0.0003904429,0.00001293206,0.00003032274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03116053,"threshold_uncertainty_score":0.3979718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02712700372941328,"score_gpt":0.3107203211354317,"score_spread":0.2835933174060185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}