{"id":"W4381149347","doi":"10.3390/cancers15123232","title":"Metabolomics-Guided Identification of a Distinctive Hepatocellular Carcinoma Signature","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Université de Montréal","keywords":"Metabolomics; Hepatocellular carcinoma; Metabolite; Nuclear magnetic resonance spectroscopy; Metabolome; Metabolic pathway; Glutathione; Liver cancer; Chemistry; Biology; Medicine; Cancer research; Pathology; Biochemistry; Metabolism; Bioinformatics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002142596,0.0004928746,0.0003461983,0.0009737085,0.0002230186,0.000485037,0.0001456137,0.0003322547,0.001061116],"category_scores_gemma":[0.0003878599,0.0001329941,0.0003957089,0.0007175725,0.0002431573,0.0002204773,0.0003537516,0.0004204981,0.0005289009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003465531,"about_ca_system_score_gemma":0.0004441229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001201959,"about_ca_topic_score_gemma":0.001821777,"domain_scores_codex":[0.9998807,0.00001310118,0.000005463748,0.00004525765,0.00003329683,0.00002221979],"domain_scores_gemma":[0.9998533,0.00002901115,0.00004032689,0.00001153256,0.00004159193,0.00002434374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003188857,0.00004963426,0.008812861,0.0001247381,0.00005374723,0.0000965093,0.00003376213,0.0008027978,0.9744256,0.0001446057,0.0002470772,0.01488976],"study_design_scores_gemma":[0.00003062869,0.0004899632,0.1599707,0.00002956558,0.0001936071,0.001125596,0.0001418037,0.03863798,0.7948707,0.0007943564,0.003656476,0.00005866549],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9582644,0.001649068,0.03352517,0.0002836055,0.0000308991,0.0001213451,0.003551985,0.0004947838,0.002078795],"genre_scores_gemma":[0.9672582,0.0009354039,0.02712805,0.0001178162,0.00002345663,0.00007396645,0.003345092,0.00007109228,0.001047054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001201959,"threshold_uncertainty_score":0.003549755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660308169549809,"score_gpt":0.2592439231705335,"score_spread":0.2426408414750354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}