{"id":"W4381168004","doi":"10.1101/2023.06.18.545491","title":"Cortical tension regulates Hippo signaling via Par-1-mediated Kibra degradation","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Hippo signaling pathway; Regulator; Cell biology; Ubiquitin; Ubiquitin ligase; Chemistry; Biology; Signal transduction; Activator (genetics); Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008840427,0.0002439484,0.0001858306,0.0002156163,0.0002374077,0.0004769471,0.0001753577,0.0002252526,0.002200793],"category_scores_gemma":[0.0001301096,0.0001422859,0.0001842754,0.0001327305,0.0002919415,0.0003189125,0.0003274044,0.0005040421,0.0007271487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000355752,"about_ca_system_score_gemma":0.0001239904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004603103,"about_ca_topic_score_gemma":0.000535716,"domain_scores_codex":[0.9998959,0.0000103352,0.00000528739,0.00002672839,0.00002815664,0.00003356464],"domain_scores_gemma":[0.9999114,0.000008300183,0.00003485867,0.000007463773,0.000009863782,0.00002805622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007523016,0.000009731696,0.0002005338,0.00001749827,0.000002787965,0.00003634522,0.000005134184,0.00004751744,0.9988797,0.0001502968,0.00007901207,0.0004961336],"study_design_scores_gemma":[0.00002353047,0.00006049403,0.0231257,0.000005773054,0.000008270267,0.0002224943,0.00004992397,0.003583414,0.9708068,0.0002508005,0.001854224,0.000008639586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869981,0.001725628,0.006619781,0.0003651051,0.00004117748,0.00001998122,0.0006693554,0.000174289,0.003386602],"genre_scores_gemma":[0.9956559,0.0004402921,0.001029081,0.00005391071,0.0000100877,0.00001413288,0.0003251415,0.00003275302,0.002438681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002200793,"threshold_uncertainty_score":0.007362366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01750205084313837,"score_gpt":0.2207275491256875,"score_spread":0.2032254982825492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}