{"id":"W4381185249","doi":"10.1038/s41588-023-01422-x","title":"Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy","year":2023,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Toronto General Hospital; University of Toronto","funders":"National Human Genome Research Institute; National Institute of Allergy and Infectious Diseases; National Center for Advancing Translational Sciences; Medical Research Council; KfH-Stiftung Präventivmedizin; Gilead Sciences; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Fresenius Medical Care North America; National Natural Science Foundation of China; Deutsche Forschungsgemeinschaft; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; Kidney Research UK; National Institute of General Medical Sciences; Bundesministerium für Bildung und Forschung; Albert-Ludwigs-Universität Freiburg; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; Natera; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Všeobecná Fakultní Nemocnice v Praze; Amgen; Pirogov Russian National Research Medical University; U.S. Department of Veterans Affairs; U.S. Department of Health and Human Services; National Science Foundation","keywords":"Biology; Genome-wide association study; Computational biology; Nephropathy; Genetics; Genetic association; Genome; Drug discovery; Drug; Bioinformatics; Gene; Genotype; Single-nucleotide polymorphism; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001129068,0.0007929014,0.0008828276,0.002061689,0.0004238789,0.001369961,0.0005330284,0.0007369144,0.0030591],"category_scores_gemma":[0.001860375,0.0002380816,0.001335415,0.001924767,0.0004037944,0.0003919248,0.0005254013,0.0009103076,0.0003303602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004131345,"about_ca_system_score_gemma":0.000750858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001511883,"about_ca_topic_score_gemma":0.003840633,"domain_scores_codex":[0.9994948,0.0001512155,0.00005191088,0.0001163546,0.0001016052,0.00008398251],"domain_scores_gemma":[0.9989195,0.0005809957,0.0002817545,0.0000492972,0.00007132625,0.00009712792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005860116,0.0004121957,0.7296467,0.0005637393,0.0062307,0.00240512,0.0001519292,0.004446242,0.1008012,0.002933718,0.004412047,0.1421363],"study_design_scores_gemma":[0.000647394,0.0009904132,0.9311658,0.0001946137,0.007176938,0.003503195,0.0004171275,0.01243106,0.02092151,0.00765811,0.01481679,0.00007706423],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671354,0.01741483,0.005911449,0.003081864,0.0001181767,0.00004329584,0.002154297,0.0002287383,0.003912013],"genre_scores_gemma":[0.9924226,0.003191766,0.002628126,0.0004548989,0.00008600027,0.00001128676,0.000757862,0.00003148105,0.0004158783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0030591,"threshold_uncertainty_score":0.0102337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01924324786133714,"score_gpt":0.2908116887480404,"score_spread":0.2715684408867033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}