{"id":"W4381189797","doi":"10.1038/s41564-023-01407-w","title":"A genetic system for Akkermansia muciniphila reveals a role for mucin foraging in gut colonization and host sterol biosynthesis gene expression","year":2023,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Health and Human Services; Government of Canada; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; American Heart Association","keywords":"Akkermansia muciniphila; Biology; Mucin; Transposon mutagenesis; Gene; Genetics; Microbiology; Transposable element; Mutant; Biochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002301964,0.0008016336,0.0004427407,0.000800722,0.0004440058,0.0004890029,0.0007083609,0.0007910082,0.001364016],"category_scores_gemma":[0.000301253,0.0003094666,0.0006063342,0.0004984858,0.0005211629,0.0002307464,0.0008256705,0.001336385,0.0006090185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006107516,"about_ca_system_score_gemma":0.0004296946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002364644,"about_ca_topic_score_gemma":0.002439387,"domain_scores_codex":[0.9997446,0.00003747776,0.00003109657,0.00006887814,0.00006310512,0.00005487246],"domain_scores_gemma":[0.99959,0.0001211434,0.000108889,0.00006114602,0.00003278496,0.00008602189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007328218,0.00001719312,0.00007548758,0.00001348768,0.000004224444,0.00003423287,0.00001123191,0.00005026577,0.9990826,0.0001260712,0.00001503894,0.0004971047],"study_design_scores_gemma":[0.00009159909,0.000560195,0.01253361,0.0000183259,0.00009359895,0.0009755868,0.0001908714,0.004064552,0.9765545,0.0003961991,0.004460385,0.00006054953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858832,0.0003206769,0.01027162,0.0004087272,0.0001499762,0.0001145152,0.001201621,0.000388826,0.00126081],"genre_scores_gemma":[0.9778699,0.0004029651,0.01481123,0.0001802056,0.00003493018,0.0001284417,0.001875082,0.0001953779,0.004501696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002364644,"threshold_uncertainty_score":0.004701734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005764984731454419,"score_gpt":0.2503962255527193,"score_spread":0.2446312408212649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}