{"id":"W4381192959","doi":"10.1089/hum.2023.016","title":"Genome Editing in Ferret Airway Epithelia Mediated by CRISPR/Nucleases Delivered with Amphiphilic Shuttle Peptides","year":2023,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Feldan (Canada)","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Genome editing; Biology; Green fluorescent protein; Reporter gene; Cell biology; Gene delivery; Transgene; Cre recombinase; In vitro; Genetic enhancement; Molecular biology; CRISPR; Gene; Genetics; Gene expression; Genetically modified mouse","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644773,0.00023102,0.0001910706,0.0001056811,0.0001074426,0.00002972819,0.0002255768,0.000108458,0.0001014508],"category_scores_gemma":[0.0000166716,0.0002129305,0.00006032194,0.000227886,0.00006525991,0.000004890739,0.00005663408,0.00009987704,0.000041693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001838758,"about_ca_system_score_gemma":0.00002445323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000065346,"about_ca_topic_score_gemma":0.0001143515,"domain_scores_codex":[0.9987778,0.00004219268,0.0002204504,0.0003996846,0.0001562805,0.0004035851],"domain_scores_gemma":[0.9994597,0.00001512133,0.00005339685,0.0003327387,0.0000458499,0.00009314548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005867018,0.00004057344,0.001947431,0.00001022844,0.00004914363,0.00001453918,0.0002322383,0.0009463981,0.9945727,0.000003199232,0.00149137,0.0006335148],"study_design_scores_gemma":[0.002251436,0.0007694526,0.05229726,0.0000302712,0.00001188701,0.00001760895,0.0003261057,0.0002496456,0.9255111,0.00005656263,0.01790952,0.0005691879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962268,0.00277706,0.0003320159,0.00008877534,0.00006399975,0.0002158496,0.0000643063,0.0000811038,0.0001501267],"genre_scores_gemma":[0.9967006,0.001443596,0.0001374611,0.0001577207,0.0003177545,0.00004702903,0.0007812796,0.00007140479,0.0003431456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06906163,"threshold_uncertainty_score":0.8683054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242282305644768,"score_gpt":0.2790385046015028,"score_spread":0.2666156815450551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}