{"id":"W4381192959","doi":"10.1089/hum.2023.016","title":"Genome Editing in Ferret Airway Epithelia Mediated by CRISPR/Nucleases Delivered with Amphiphilic Shuttle Peptides","year":2023,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Feldan (Canada)","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Genome editing; Biology; Green fluorescent protein; Reporter gene; Cell biology; Gene delivery; Transgene; Cre recombinase; In vitro; Genetic enhancement; Molecular biology; CRISPR; Gene; Genetics; Gene expression; Genetically modified mouse","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003077627,0.0003630485,0.0002826543,0.0001854686,0.0001567567,0.0003101119,0.0001772258,0.0003963029,0.0004227156],"category_scores_gemma":[0.0001776753,0.0001026418,0.0002782303,0.00008037737,0.0003280309,0.0002344848,0.00017833,0.0005224043,0.0001627864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002775826,"about_ca_system_score_gemma":0.000140165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007781579,"about_ca_topic_score_gemma":0.001127626,"domain_scores_codex":[0.9997777,0.00004138589,0.00002419722,0.00006154658,0.00006033355,0.00003488846],"domain_scores_gemma":[0.9998283,0.00004772828,0.00006206688,0.00001844977,0.00001808759,0.00002523168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000126562,0.000005458013,0.00008304125,0.00001057764,0.000001331696,0.00002166556,0.000008893224,0.00003575701,0.9995534,0.000017931,0.000005709909,0.0002436925],"study_design_scores_gemma":[0.000001848334,0.00008490511,0.0009975957,0.000002088376,0.000003697157,0.000076471,0.00001339644,0.00047359,0.9979494,0.00001067568,0.0003839254,0.000002413703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923925,0.000347006,0.006487542,0.00003561114,0.00001405529,0.00003362525,0.0001368839,0.00008051535,0.0004721044],"genre_scores_gemma":[0.9908562,0.0003697888,0.007006007,0.00003532911,0.00000431362,0.00004398331,0.0002646456,0.00003209772,0.001387669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007781579,"threshold_uncertainty_score":0.002013981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242282305644768,"score_gpt":0.2790385046015028,"score_spread":0.2666156815450551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}