{"id":"W4381248768","doi":"10.1038/s41588-023-01429-4","title":"Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia","year":2023,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation; University Health Network; American Society of Hematology; V Foundation for Cancer Research","keywords":"Biology; Leukemia; Transcriptome; Cancer research; Tyrosine kinase; Progenitor cell; Stem cell; Immunology; Genetics; Signal transduction; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009780944,0.000218623,0.0003824541,0.0002093674,0.00003988216,0.000007950331,0.0001610916,0.0004863538,0.0001336272],"category_scores_gemma":[0.0001175033,0.0001916336,0.0001556185,0.000636912,0.00009113145,0.00002277611,0.00004069554,0.0004104243,0.0001968466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008384101,"about_ca_system_score_gemma":0.001038043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001517392,"about_ca_topic_score_gemma":0.00001827595,"domain_scores_codex":[0.9985107,0.00002483089,0.0003201814,0.0003251206,0.0004467977,0.0003723812],"domain_scores_gemma":[0.9990404,0.0001092499,0.00008411138,0.0005029318,0.0001182095,0.0001451241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00155833,0.0007749635,0.2644206,0.003375577,0.002326234,0.001294434,0.002660275,0.003026437,0.4753917,0.0008081864,0.1670059,0.07735731],"study_design_scores_gemma":[0.01539175,0.001251014,0.5399941,0.0006138959,0.00128802,0.0003181444,0.0003299104,0.009553899,0.3434224,0.0007517062,0.0864152,0.0006700165],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920036,0.004067443,0.00003634865,0.0002307313,0.0006189056,0.0003361894,0.00004628989,0.0001717396,0.002488806],"genre_scores_gemma":[0.9945889,0.001319981,0.001236653,0.0003066344,0.0002348192,0.00001444507,0.0001098315,0.00005538444,0.002133341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2755735,"threshold_uncertainty_score":0.781459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01338249891014875,"score_gpt":0.278462186968016,"score_spread":0.2650796880578672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}