{"id":"W4381249184","doi":"10.1177/1759720x231177116","title":"Emerging molecular biomarkers in osteoarthritis pathology","year":2023,"lang":"en","type":"review","venue":"Therapeutic Advances in Musculoskeletal Disease","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canada Research Chairs","keywords":"Osteoarthritis; Medicine; Synovial fluid; Molecular biomarkers; Biomarker; Disease; Biomarker discovery; Narrative review; Bioinformatics; Pathological; Arthritis; Cartilage; Pathology; Internal medicine; Proteomics; Intensive care medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001020517,0.0009446209,0.001566003,0.003378876,0.0002955717,0.001565602,0.0007725419,0.00134088,0.005646803],"category_scores_gemma":[0.001544903,0.0003021245,0.000884292,0.002590912,0.0005645448,0.001673744,0.0009208833,0.0019912,0.002465718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007692772,"about_ca_system_score_gemma":0.001533115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000982313,"about_ca_topic_score_gemma":0.001689679,"domain_scores_codex":[0.9995489,0.0000928865,0.00007479123,0.00005894666,0.0001794745,0.00004503076],"domain_scores_gemma":[0.9992129,0.0003667834,0.000113113,0.0000234905,0.0002426259,0.0000410238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000901813,0.00006908114,0.0003281823,0.03301786,0.000190253,0.0002430756,0.0001104415,0.0003499251,0.003204774,0.00683764,0.02772192,0.9278366],"study_design_scores_gemma":[0.0000157042,0.0000975596,0.0009348013,0.006720932,0.0001872418,0.0009940413,0.00008219088,0.0001074262,0.0008540356,0.002970893,0.9870096,0.00002547597],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001118019,0.9982933,0.0001617737,0.0003071413,0.000265137,0.000007350622,0.00002615738,0.000009284421,0.0008179339],"genre_scores_gemma":[0.0008662291,0.9978119,0.00025603,0.0002363698,0.0001901706,0.00001021137,0.00004887961,0.00000166855,0.0005785254],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005646803,"threshold_uncertainty_score":0.01889044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02246877442811193,"score_gpt":0.3633000855689297,"score_spread":0.3408313111408178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}