{"id":"W4381251182","doi":"10.1016/j.isci.2023.107180","title":"Contact sites between endoplasmic reticulum sheets and mitochondria regulate mitochondrial DNA replication and segregation","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université du Québec à Trois-Rivières; University of Calgary; McGill University; Université du Québec; Université du Québec à Montréal","funders":"Qatar University; Canadian Institutes of Health Research; Fondation de l’UQTR; Natural Sciences and Engineering Research Council of Canada; Centre d’Excellence en Recherche sur les Maladies Orphelines – Fondation Courtois; Canada Foundation for Innovation","keywords":"Mitochondrial DNA; Mitochondrion; Mitochondrial fission; Endoplasmic reticulum; Cell biology; mitochondrial fusion; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582667,0.0003087434,0.0003060577,0.0002123633,0.0004453544,0.0007860797,0.0003338346,0.0004531188,0.001410865],"category_scores_gemma":[0.0002034854,0.0002170133,0.000201829,0.0001594425,0.0002946176,0.0007442169,0.0006597624,0.0005910486,0.001207133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003190545,"about_ca_system_score_gemma":0.0001575216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001658574,"about_ca_topic_score_gemma":0.0002211771,"domain_scores_codex":[0.9998385,0.00002503143,0.00001138254,0.00004712688,0.00004944199,0.00002857463],"domain_scores_gemma":[0.9997715,0.00002295922,0.00007946417,0.00002304459,0.00004039037,0.00006258886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001182937,0.00001545099,0.0004895789,0.00003679433,0.000004232847,0.0001640363,0.00003853252,0.00009520069,0.9968342,0.0004996859,0.00008092958,0.001623094],"study_design_scores_gemma":[0.00002368969,0.0001012694,0.01961954,0.00002195251,0.0000184895,0.0006025524,0.0002041814,0.003098788,0.9691707,0.0006191005,0.006505307,0.000014377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785762,0.005134462,0.01119821,0.0002510792,0.00006811889,0.0000275126,0.0001736008,0.0002574887,0.004313334],"genre_scores_gemma":[0.9932069,0.001142404,0.002249918,0.00004137017,0.00001466562,0.00001591125,0.0001787041,0.00003296064,0.003117135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001410865,"threshold_uncertainty_score":0.004719853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817325003746546,"score_gpt":0.264680003233813,"score_spread":0.2465067531963476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}