{"id":"W4381252706","doi":"10.1016/j.jhepr.2023.100817","title":"Efficacy of antiviral therapy and host–virus interactions visualised using serial liver sampling with fine-needle aspirates","year":2023,"lang":"en","type":"article","venue":"JHEP Reports","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Vir Biotechnology; Janssen Pharmaceuticals; Gilead Research Scholars; Gilead Sciences; GlaxoSmithKline","keywords":"Biology; Virology; RNA; Viral replication; Deep sequencing; Hepatitis B virus; Viral load; HBx; Virus; Transcription (linguistics); Gene; Genome; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006324921,0.0002293912,0.0002967638,0.0004124044,0.0001037091,0.0003337783,0.0001338942,0.0002933784,0.001088157],"category_scores_gemma":[0.0006719899,0.000132399,0.0001798055,0.000165322,0.0002613482,0.0002325819,0.0001641825,0.0003492036,0.0002872575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001845032,"about_ca_system_score_gemma":0.00009450983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004521766,"about_ca_topic_score_gemma":0.0004918651,"domain_scores_codex":[0.9997318,0.00007577474,0.00001989117,0.00004928279,0.00009606891,0.00002717261],"domain_scores_gemma":[0.9994134,0.0002717842,0.000124781,0.0000420535,0.00009022713,0.00005789027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001918489,0.0001245982,0.01166897,0.0000817562,0.00002412145,0.0000997649,0.00007971068,0.0003186223,0.970172,0.00002883955,0.00005047,0.01543254],"study_design_scores_gemma":[0.00004370993,0.004302809,0.1317344,0.00001190043,0.00007945142,0.0006114676,0.0001050553,0.006771231,0.8552932,0.0001009263,0.0009268951,0.00001905302],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856524,0.002477098,0.009737093,0.0000501235,0.00002906772,0.00008129937,0.0002648339,0.0001820348,0.001525934],"genre_scores_gemma":[0.9926139,0.0005621663,0.005743761,0.00005013429,0.00001930265,0.00005301528,0.0002304597,0.00001765119,0.0007096627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001088157,"threshold_uncertainty_score":0.003640175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1056441041990603,"score_gpt":0.3653618667268447,"score_spread":0.2597177625277844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}