{"id":"W4381273483","doi":"10.21518/ms2023-052","title":"Bioequivalence and immunogenicity of insulin LisPro biosimilar compared to reference drug","year":2023,"lang":"en","type":"article","venue":"Meditsinskiy sovet = Medical Council","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Defence Medical Centre","funders":"","keywords":"Bioequivalence; Medicine; Pharmacokinetics; Insulin lispro; Insulin; Crossover study; Immunogenicity; Area under the curve; Confidence interval; Pharmacodynamics; Cmax; Pharmacology; Internal medicine; Hypoglycemia; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003285235,0.0003495919,0.0006627078,0.0004445077,0.0001302742,0.0004921129,0.0002804713,0.0005533667,0.002024659],"category_scores_gemma":[0.003278645,0.0001692843,0.0006823725,0.0004189518,0.0005789249,0.0004058646,0.0002513471,0.000650512,0.000283288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000297157,"about_ca_system_score_gemma":0.000286992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001216018,"about_ca_topic_score_gemma":0.00006513498,"domain_scores_codex":[0.9971592,0.00147307,0.0002206218,0.0003730387,0.0006805396,0.00009348933],"domain_scores_gemma":[0.998185,0.000513684,0.00068926,0.0002046131,0.0002446084,0.0001628623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.363498,0.01522734,0.02481637,0.002173519,0.002341162,0.0002942313,0.0009689095,0.004851913,0.3991848,0.00179216,0.00171838,0.1831332],"study_design_scores_gemma":[0.03238185,0.6827965,0.112538,0.000173897,0.001959515,0.001491183,0.0002059705,0.01319615,0.1434936,0.001441544,0.01021047,0.0001113628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948974,0.002212609,0.00155695,0.00006318815,0.00007943397,0.0002094446,0.000266631,0.00002653194,0.0006877739],"genre_scores_gemma":[0.9978644,0.0003958171,0.0008364714,0.0000655101,0.00006487557,0.0001533039,0.0003402204,0.0000077949,0.0002716463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003285235,"threshold_uncertainty_score":0.01737416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09385972665149749,"score_gpt":0.3159028409374231,"score_spread":0.2220431142859256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}