{"id":"W4381273483","doi":"10.21518/ms2023-052","title":"Bioequivalence and immunogenicity of insulin LisPro biosimilar compared to reference drug","year":2023,"lang":"en","type":"article","venue":"Meditsinskiy sovet = Medical Council","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Defence Medical Centre","funders":"","keywords":"Bioequivalence; Medicine; Pharmacokinetics; Insulin lispro; Insulin; Crossover study; Immunogenicity; Area under the curve; Confidence interval; Pharmacodynamics; Cmax; Pharmacology; Internal medicine; Hypoglycemia; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004270006,0.0003269608,0.0007743539,0.000157343,0.0001759913,0.00001943744,0.0007250195,0.0005936003,0.001674695],"category_scores_gemma":[0.006942068,0.0002514152,0.0001194801,0.001000615,0.001245495,0.00007741297,0.0005498471,0.0007135966,0.0003789772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001365056,"about_ca_system_score_gemma":0.0007972013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004249348,"about_ca_topic_score_gemma":0.0003037956,"domain_scores_codex":[0.9966505,0.0003983187,0.0007864048,0.0006602918,0.0007974598,0.0007070308],"domain_scores_gemma":[0.9974921,0.0009183353,0.0001619931,0.0005451311,0.0005980764,0.0002843259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001644372,0.0009096567,0.004061462,0.0006400243,0.0008132772,0.0001629364,0.00322744,0.000003007101,0.3669754,0.002758126,0.5203887,0.09841558],"study_design_scores_gemma":[0.00426313,0.0007110984,0.02306711,0.0006792106,0.0002447058,0.00009568685,0.0008570595,0.0003350416,0.1271038,0.001441352,0.8402173,0.0009845246],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567408,0.01024481,0.0004950404,0.02280119,0.003205966,0.0007915491,0.0007116812,0.00046877,0.004540185],"genre_scores_gemma":[0.9909781,0.002554443,0.0009290887,0.003308847,0.0001214576,0.00003513696,0.00006411324,0.00003089475,0.001977934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3198286,"threshold_uncertainty_score":0.9999938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09385972665149749,"score_gpt":0.3159028409374231,"score_spread":0.2220431142859256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}