{"id":"W4381331511","doi":"10.1016/s0140-6736(23)00731-6","title":"Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":113,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; University of Manitoba; CancerCare Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Rare Diseases Clinical Research Network; Office of Naval Research; National Center for Advancing Translational Sciences; Health Resources and Services Administration; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; National Institute of Neurological Disorders and Stroke; California Institute of Regenerative Medicine; NHLBI Division of Intramural Research; Texas Children's Hospital","keywords":"Medicine; Primary immunodeficiency; Severe combined immunodeficiency; Newborn screening; Hematopoietic cell; Transplantation; Immune system; Hematopoietic stem cell transplantation; Immunodeficiency; Immunologic Deficiency Syndromes; Pediatrics; Haematopoiesis; Immunology; Internal medicine; Stem cell; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001597251,0.0003328047,0.0007088034,0.00005836777,0.0008862762,0.00004614085,0.0008537355,0.0001022826,0.00004705089],"category_scores_gemma":[0.00006852551,0.0001593834,0.0002764377,0.0003640778,0.000358801,0.00006285129,0.00008851434,0.0003219999,0.0001056148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003903593,"about_ca_system_score_gemma":0.00005303444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006498757,"about_ca_topic_score_gemma":0.00002775043,"domain_scores_codex":[0.9975222,0.000897748,0.000494344,0.0003672431,0.000139736,0.0005787265],"domain_scores_gemma":[0.9964911,0.002269514,0.0002343426,0.0009511816,0.00004849206,0.000005334861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1079566,0.004146771,0.4329453,0.0009793312,0.003654812,0.00006305608,0.09783929,0.007866304,0.2668433,0.001265361,0.0006668727,0.07577294],"study_design_scores_gemma":[0.01075292,0.002453913,0.966094,0.0001321844,0.0005961189,0.00001114905,0.004372889,0.00003626352,0.01454642,0.0001085969,0.0006161667,0.0002793938],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871747,0.008596554,0.0003048079,0.0006026914,0.0005850643,0.001867122,0.000228728,0.0001037717,0.0005365378],"genre_scores_gemma":[0.9988633,0.0002147967,0.00001154169,0.00005820627,0.00001763659,0.000385939,0.0002000656,0.0000302308,0.0002182854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5331486,"threshold_uncertainty_score":0.681661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838392702424207,"score_gpt":0.2512093776048763,"score_spread":0.2228254505806342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}