{"id":"W4381331511","doi":"10.1016/s0140-6736(23)00731-6","title":"Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":113,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; University of Manitoba; CancerCare Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Rare Diseases Clinical Research Network; Office of Naval Research; National Center for Advancing Translational Sciences; Health Resources and Services Administration; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; National Institute of Neurological Disorders and Stroke; California Institute of Regenerative Medicine; NHLBI Division of Intramural Research; Texas Children's Hospital","keywords":"Medicine; Primary immunodeficiency; Severe combined immunodeficiency; Newborn screening; Hematopoietic cell; Transplantation; Immune system; Hematopoietic stem cell transplantation; Immunodeficiency; Immunologic Deficiency Syndromes; Pediatrics; Haematopoiesis; Immunology; Internal medicine; Stem cell; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005673977,0.0007227999,0.0007217646,0.0008278369,0.001257709,0.00127739,0.001450411,0.001894202,0.0007425019],"category_scores_gemma":[0.01139613,0.0007814885,0.001664867,0.001683912,0.0008406787,0.0009791837,0.001621716,0.002146975,0.0002598721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001368725,"about_ca_system_score_gemma":0.001523589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1009552,"about_ca_topic_score_gemma":0.06276367,"domain_scores_codex":[0.9971795,0.001269737,0.0002201638,0.0005223007,0.0003106517,0.0004977303],"domain_scores_gemma":[0.9912472,0.001833527,0.002934532,0.001191161,0.001123169,0.001670442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005011709,0.0001166031,0.9978179,0.000006181989,0.000195497,0.00007181051,0.0002297664,0.0000455735,0.0001061289,0.00001219811,0.000150967,0.0007462416],"study_design_scores_gemma":[0.00001625998,0.0002775044,0.998995,0.000007143011,0.0001191712,0.00008147713,0.0002619323,0.00008348873,0.00003428472,0.00001164875,0.0001044025,0.00000771659],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986583,0.0003045951,0.0000476184,0.000173781,0.00001172879,0.000007460806,0.0006344486,0.000003498884,0.0001585611],"genre_scores_gemma":[0.9983663,0.0002139124,0.00008286665,0.00009124535,0.00001096697,0.00001352322,0.0009722163,0.000004142673,0.0002449537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1009552,"threshold_uncertainty_score":0.2007351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838392702424207,"score_gpt":0.2512093776048763,"score_spread":0.2228254505806342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}