{"id":"W4381336836","doi":"10.1093/bjd/ljad162.016","title":"390 Efficacy and safety of roflumilast cream 0.15% in adults and children aged ≥6 years with mild to moderate atopic dermatitis in two phase 3 trials (INTEGUMENT-1 and INTEGUMENT-2)","year":2023,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Probity Medical Research; Queen's University","funders":"","keywords":"Integument; Atopic dermatitis; Roflumilast; Medicine; Eczema Area and Severity Index; Clinical endpoint; Randomized controlled trial; Internal medicine; Dermatology; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001905148,0.0006700701,0.001819714,0.0002424953,0.0003603418,0.0006745073,0.0004650364,0.001063135,0.003057376],"category_scores_gemma":[0.001403691,0.0004112273,0.00166782,0.0002613308,0.0004161597,0.0005235408,0.0003305209,0.001677597,0.0004895031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006679145,"about_ca_system_score_gemma":0.001087979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001466539,"about_ca_topic_score_gemma":0.004750995,"domain_scores_codex":[0.9992568,0.0003452461,0.0000717695,0.0001179021,0.00009006257,0.0001182899],"domain_scores_gemma":[0.9992597,0.0001690468,0.0002244604,0.00003451985,0.00006583489,0.0002465246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8167467,0.02108268,0.02815004,0.002282022,0.002479156,0.0004832245,0.0004784753,0.0004224721,0.02079145,0.0002043381,0.003711999,0.1031673],"study_design_scores_gemma":[0.6098678,0.2677417,0.1116986,0.0002449013,0.001698638,0.0006572233,0.0002253155,0.0004238686,0.002415559,0.00011344,0.004869745,0.00004307223],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853132,0.01018301,0.0002264786,0.0003804813,0.0001303594,0.00119981,0.001238814,0.00003835114,0.001289474],"genre_scores_gemma":[0.9912598,0.003741492,0.0006823358,0.0006624604,0.0001488317,0.001372414,0.001375814,0.00001093499,0.0007460535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003057376,"threshold_uncertainty_score":0.01022798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289644150998946,"score_gpt":0.3020527063558678,"score_spread":0.2891562648458783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}