{"id":"W4381336871","doi":"10.1093/bjd/ljad162.030","title":"409 Efficacy and safety of upadacitinib in adults and adolescents with moderate-to-severe atopic dermatitis: subgroup analysis of the Measure Up 1, Measure Up 2 and AD Up phase 3 clinical trials at 52 weeks","year":2023,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; SKiN Health; University of Calgary","funders":"","keywords":"Medicine; Atopic dermatitis; Eczema Area and Severity Index; Discontinuation; Dermatology Life Quality Index; Adverse effect; Placebo; Randomized controlled trial; Internal medicine; Concomitant; Clinical trial; Quality of life (healthcare); Pediatrics; Dermatology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003071149,0.000709804,0.002819765,0.0004190774,0.000264321,0.001056931,0.0004238169,0.0009288157,0.001685196],"category_scores_gemma":[0.002429768,0.0002948758,0.004438794,0.0004877318,0.0002878993,0.0005934383,0.0003991922,0.001338291,0.0001779279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004936591,"about_ca_system_score_gemma":0.0007146343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005409634,"about_ca_topic_score_gemma":0.00199833,"domain_scores_codex":[0.9986635,0.0007228742,0.0002180121,0.0001304922,0.0001330455,0.00013197],"domain_scores_gemma":[0.9988471,0.0004133765,0.0003527687,0.0001192473,0.0001013386,0.000166036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8984315,0.002189535,0.02021579,0.002328791,0.01999226,0.0001558564,0.0001431151,0.001063271,0.006411037,0.000193272,0.001474975,0.04740051],"study_design_scores_gemma":[0.5604245,0.2134722,0.1641293,0.0007546345,0.0452456,0.0007239243,0.0003293525,0.003240041,0.003645998,0.000849381,0.007069489,0.0001156865],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780662,0.01716867,0.0004537726,0.0002719222,0.0001130454,0.001415871,0.001247069,0.00003023868,0.001233082],"genre_scores_gemma":[0.9948558,0.001932059,0.000449724,0.000335272,0.00009013299,0.001025731,0.0009581151,0.000007085952,0.000346029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003071149,"threshold_uncertainty_score":0.01624197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0379691304272818,"score_gpt":0.3412072024070543,"score_spread":0.3032380719797725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}