{"id":"W4381376749","doi":"10.2337/db23-221-lb","title":"221-LB: Identification of PAM as Novel Monogenic Diabetes Gene","year":2023,"lang":"en","type":"article","venue":"Diabetes","topic":"Nutrition, Genetics, and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences","funders":"","keywords":"Mendelian randomization; Genome-wide association study; Genetic association; Type 2 diabetes; Genetics; Biology; Glucokinase; Candidate gene; Single-nucleotide polymorphism; Gene; Internal medicine; Diabetes mellitus; Medicine; Genetic variants; Endocrinology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001315803,0.0003847081,0.0003990632,0.0007335288,0.0003808184,0.0005327775,0.0004056958,0.0007411944,0.004796669],"category_scores_gemma":[0.0004929462,0.0001140677,0.0004695824,0.000831686,0.0002395792,0.0001393672,0.0003840555,0.0005422361,0.001394854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002004046,"about_ca_system_score_gemma":0.0001970933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003942433,"about_ca_topic_score_gemma":0.0004045542,"domain_scores_codex":[0.9998906,0.00001445273,0.00001046406,0.00004537955,0.00002117086,0.00001790091],"domain_scores_gemma":[0.999814,0.00003744799,0.00005638054,0.00001733136,0.00001337485,0.00006151303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006318729,0.0008073177,0.2806659,0.0009821088,0.0003773821,0.08463923,0.0005043371,0.001081144,0.5223356,0.003093611,0.004784529,0.09441017],"study_design_scores_gemma":[0.0004690835,0.001288366,0.6752489,0.0002228911,0.0007140791,0.2170683,0.0003211796,0.008272829,0.06377328,0.003160973,0.02938334,0.00007666852],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920893,0.001220504,0.002538088,0.0005044357,0.00009037158,0.00004635942,0.001144625,0.0001452849,0.002221011],"genre_scores_gemma":[0.9915693,0.0003917138,0.003477489,0.0003111118,0.0001264336,0.0000289087,0.002026532,0.00002109438,0.002047282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004796669,"threshold_uncertainty_score":0.01604652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009507930246652458,"score_gpt":0.2411684920429437,"score_spread":0.2316605617962913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}