{"id":"W4381377492","doi":"10.2337/db23-91-lb","title":"91-LB: COVALENT-111, a Phase 1/2 Trial of BMF-219, a Covalent Menin Inhibitor, in Patients with Type 2 Diabetes Mellitus—Preliminary Results","year":2023,"lang":"en","type":"article","venue":"Diabetes","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Glycemic; Diabetes mellitus; Regimen; Clinical trial; Placebo; Internal medicine; Type 2 Diabetes Mellitus; Hypoglycemia; Endocrinology; Pediatrics; Alternative medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009482215,0.001192919,0.00111801,0.0003108511,0.0003722418,0.0007710611,0.0006293874,0.001170439,0.003935461],"category_scores_gemma":[0.0004595163,0.0003684195,0.00109103,0.0002453405,0.0004666756,0.0004559415,0.0003119013,0.002079999,0.0006165672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003843267,"about_ca_system_score_gemma":0.0006376447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009266147,"about_ca_topic_score_gemma":0.002639701,"domain_scores_codex":[0.9997255,0.0001151625,0.00001896358,0.00003718086,0.00003486402,0.00006829755],"domain_scores_gemma":[0.9997578,0.00003660435,0.00005254874,0.00001691002,0.00001794511,0.0001181017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5779948,0.05632126,0.007798796,0.001882095,0.002196278,0.0004785372,0.0002618934,0.001673216,0.1104395,0.0004778476,0.008717819,0.2317579],"study_design_scores_gemma":[0.6411206,0.3304749,0.01445573,0.00005609311,0.0006975863,0.0004523384,0.00006540623,0.001009675,0.006316151,0.000145657,0.005162089,0.00004386721],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885358,0.002976421,0.0007364285,0.0006558622,0.0001711023,0.002494961,0.001533345,0.0002251243,0.002670939],"genre_scores_gemma":[0.9808182,0.003032209,0.003177149,0.001851953,0.000336063,0.002239679,0.0039211,0.00005885197,0.004564918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003935461,"threshold_uncertainty_score":0.01316541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01059701319825155,"score_gpt":0.2497003210590903,"score_spread":0.2391033078608387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}