{"id":"W4381377969","doi":"10.2337/db23-52-or","title":"52-OR: Effect of Oral Nonpeptide GLP-1 Receptor Agonist Orforglipron (LY3502970) in Participants with Obesity or Overweight—A Phase 2 Study","year":2023,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Placebo; Weight loss; Tolerability; Overweight; Waist; Obesity; Internal medicine; Weight change; Clinical endpoint; Body mass index; Adverse effect; Gastroenterology; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001097746,0.001215338,0.001850679,0.0003497821,0.0002498066,0.0006573319,0.0004908518,0.001501358,0.005445296],"category_scores_gemma":[0.0005081248,0.0004426626,0.001691967,0.0001994328,0.000398854,0.0007579163,0.0002933521,0.001879454,0.0009740972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003003582,"about_ca_system_score_gemma":0.0005348371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003609336,"about_ca_topic_score_gemma":0.001066603,"domain_scores_codex":[0.9997553,0.00009209807,0.00001498175,0.00004468249,0.00002438123,0.00006844265],"domain_scores_gemma":[0.9997695,0.00003705078,0.00004480517,0.00002051745,0.00002109516,0.000107015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8192167,0.04193413,0.002758118,0.001555418,0.001260981,0.0003264765,0.0001405659,0.0006649087,0.05452776,0.0002010841,0.002505169,0.07490883],"study_design_scores_gemma":[0.6070598,0.3715018,0.01365741,0.0001013796,0.0006795198,0.0002786673,0.00007164496,0.0007279998,0.003215442,0.0002014767,0.002458482,0.00004643218],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904442,0.003198159,0.0005803995,0.0003592392,0.0001844909,0.00180254,0.001307453,0.0001839448,0.001939563],"genre_scores_gemma":[0.9837645,0.002850791,0.001773588,0.001498412,0.000205261,0.002988927,0.002045981,0.00004612385,0.004826451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005445296,"threshold_uncertainty_score":0.01821637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02793466230771992,"score_gpt":0.3226337539480178,"score_spread":0.2946990916402979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}