{"id":"W4381429589","doi":"10.26508/lsa.202301938","title":"Clec12a inhibits MSU-induced immune activation through lipid raft expulsion","year":2023,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research; Tsinghua University; National Natural Science Foundation of China; Government of Canada","keywords":"Lipid raft; Cell biology; Syk; Phosphorylation; Signal transduction; Chemistry; Receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003079993,0.0001688116,0.0001425807,0.0000483109,0.0003098574,0.00006723557,0.0004844984,0.0001256442,0.0000322149],"category_scores_gemma":[0.0002741953,0.0001487486,0.00007019762,0.0009690981,0.0002126256,0.00005609134,0.0002090863,0.0001217244,0.0001342217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000203101,"about_ca_system_score_gemma":0.0002327756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002337768,"about_ca_topic_score_gemma":0.000004974939,"domain_scores_codex":[0.9982788,0.00002699202,0.0002321586,0.0006029518,0.000396554,0.0004625738],"domain_scores_gemma":[0.9991235,0.00001006923,0.0001087356,0.0005116932,0.0001269207,0.000119114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002352078,0.00001734063,0.0003520618,0.00001020179,0.000003460445,9.373421e-7,0.0001137521,0.00002681424,0.9954652,0.00005879523,0.0006805949,0.003247322],"study_design_scores_gemma":[0.0003038508,0.0001090676,0.01761674,0.00003259562,0.000005303378,0.000003432275,0.0001079732,0.00003259413,0.9718689,0.00003486054,0.009680897,0.0002037966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969739,0.00003869017,0.000106464,0.0008450901,0.0008326111,0.0002188026,0.000004448498,0.00006347014,0.0009165708],"genre_scores_gemma":[0.9968384,0.0001659649,0.0004150301,0.0007778416,0.0006603131,0.00002961675,0.00004953328,0.00001804106,0.001045262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02359631,"threshold_uncertainty_score":0.6065791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02723497418659098,"score_gpt":0.3032631122450166,"score_spread":0.2760281380584256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}