{"id":"W4381430657","doi":"10.1016/j.cjca.2023.06.013","title":"New Approaches Targeting the Renin-Angiotensin System: Inhibition of Brain Aminopeptidase A, ACE2 Ubiquitination, and Angiotensinogen","year":2023,"lang":"en","type":"review","venue":"Canadian Journal of Cardiology","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Collège de France; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; National Heart, Lung, and Blood Institute; Alnylam Pharmaceuticals; U.S. Department of Veterans Affairs","keywords":"Renin–angiotensin system; Medicine; Angiotensin-converting enzyme 2; Downregulation and upregulation; Blood pressure; Pharmacology; Angiotensin II; Aminopeptidase; Angiotensin-converting enzyme; Enzyme; Endocrinology; Internal medicine; Amino acid; Biochemistry; Biology; Gene; Leucine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004045983,0.0007700344,0.001313191,0.001936458,0.0002238942,0.0007012836,0.0005463546,0.0007658442,0.002730098],"category_scores_gemma":[0.0003778971,0.0002467221,0.0007038607,0.001331873,0.0003217652,0.0008744386,0.0004325237,0.001648539,0.001172713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004720663,"about_ca_system_score_gemma":0.0008607616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001144766,"about_ca_topic_score_gemma":0.002903483,"domain_scores_codex":[0.999871,0.00002130495,0.00001775172,0.00002246306,0.00005164161,0.00001585073],"domain_scores_gemma":[0.9998757,0.00005444488,0.00002124066,0.000004392233,0.00003040313,0.00001382898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001756046,0.0001408102,0.0001580011,0.03301108,0.0002939459,0.0002733999,0.00005894175,0.0003021569,0.006352499,0.003543648,0.02262025,0.9330698],"study_design_scores_gemma":[0.0001048087,0.0002818599,0.001487815,0.005618688,0.0003923133,0.00184686,0.00007369219,0.0001260757,0.001857785,0.00225329,0.9859263,0.00003059659],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001286126,0.9991063,0.00008260533,0.000134497,0.0001150363,0.00000376431,0.000009709695,0.000004873089,0.0004144499],"genre_scores_gemma":[0.0007790339,0.9984372,0.0001693613,0.0001512797,0.00008227633,0.000006296946,0.00002055007,0.000001026761,0.0003529482],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002730098,"threshold_uncertainty_score":0.009133101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08814022131446969,"score_gpt":0.2910716526822484,"score_spread":0.2029314313677787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}