{"id":"W4381432934","doi":"10.1212/nxi.0000000000200121","title":"Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis","year":2023,"lang":"en","type":"article","venue":"Neurology Neuroimmunology & Neuroinflammation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Aseptic meningitis; Canakinumab; Medicine; Meningitis; Complement factor I; Immunology; Complement system; Inflammation; Complement (music); Monoclonal antibody; Antibody; Gene; Internal medicine; Pediatrics; Genetics; Biology; Anakinra; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002032476,0.0006723823,0.0006843011,0.0005807786,0.0008294288,0.0003920455,0.0004902,0.001709156,0.0008345907],"category_scores_gemma":[0.001078333,0.0001983916,0.0004477619,0.0003617881,0.0006182044,0.0003298341,0.0003163362,0.00112422,0.0002905781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004460612,"about_ca_system_score_gemma":0.0003446999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150155,"about_ca_topic_score_gemma":0.001163018,"domain_scores_codex":[0.9997709,0.00004343582,0.00001994373,0.00003679593,0.00004154517,0.00008738069],"domain_scores_gemma":[0.999671,0.00008010564,0.00007777399,0.00002440909,0.00002331089,0.0001233129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001470686,0.00007766765,0.009265368,0.00003186751,0.00001989704,0.9825382,0.0001362574,0.0001176725,0.002982729,0.0001833207,0.0003945995,0.004105472],"study_design_scores_gemma":[0.00005932198,0.0003474448,0.01473992,0.00002258165,0.0000373689,0.9817287,0.00008082359,0.0004251193,0.001158693,0.0001262799,0.001262232,0.00001141861],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819171,0.00718516,0.00152698,0.001622472,0.0001821089,0.0000801431,0.00006864515,0.0001702604,0.007247078],"genre_scores_gemma":[0.9980782,0.0007357113,0.0002362143,0.0003039538,0.0001469632,0.00000679579,0.00003084901,0.000007739276,0.0004535336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001709156,"threshold_uncertainty_score":0.003236473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03321239040554943,"score_gpt":0.2737571868326458,"score_spread":0.2405447964270963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}