{"id":"W4381432983","doi":"10.1186/s13058-023-01673-w","title":"Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium","year":2023,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Toronto; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Cancer Institute; NIHR Cambridge Biomedical Research Centre; Canadian Institutes of Health Research; Centre Léon Bérard; Manchester Biomedical Research Centre; Universitätsklinikum Köln; Direction Générale de l’offre de Soins; National Health and Medical Research Council; Institut National Du Cancer; Deutsche Krebshilfe; Cancer Research UK; KWF Kankerbestrijding; Fondation ARC pour la Recherche sur le Cancer; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Institut Gustave-Roussy; Vrije Universiteit Amsterdam; Erasmus Medisch Centrum; Universiteit Maastricht; Radboud Universiteit; Bundesministerium für Bildung und Forschung; Transcan; National Breast Cancer Foundation; Medical Research Council; Leids Universitair Medisch Centrum; Universiteit Leiden; Cancer Australia; Fondation de France; Radboud Universitair Medisch Centrum; Canadian Breast Cancer Research Alliance; Maastricht Universitair Medisch Centrum; Rijksuniversiteit Groningen; Amsterdam University Medical Centers; National Institute for Health and Care Research","keywords":"Surgical oncology; Breast cancer; Oncology; Medicine; Body mass index; Internal medicine; Cohort; Cancer; Gynecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001772231,0.000498788,0.0005357552,0.0008033721,0.0006476472,0.000900074,0.000629269,0.0006137731,0.001180539],"category_scores_gemma":[0.002338711,0.000480092,0.0007842219,0.00150867,0.000297689,0.0003316544,0.0007077523,0.0006311986,0.0001643502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002795125,"about_ca_system_score_gemma":0.0004741134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01528168,"about_ca_topic_score_gemma":0.01383152,"domain_scores_codex":[0.9991339,0.0002116881,0.00007805439,0.0003099273,0.0001761228,0.00009038032],"domain_scores_gemma":[0.9983523,0.000214859,0.000422689,0.0004418382,0.0002527157,0.0003156775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004340354,0.00002381251,0.9974383,0.000009528805,0.0004650032,0.00006654783,0.00002743465,0.00006919853,0.0005572555,0.00001713519,0.0001991653,0.0006924494],"study_design_scores_gemma":[0.00004273873,0.00008805464,0.9986124,0.00000526947,0.0003418621,0.0002336835,0.00004742519,0.0002052628,0.0001404339,0.00001975869,0.0002572942,0.00000591033],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960095,0.000544637,0.0003805552,0.00005912144,0.00001512606,0.00002369188,0.002620982,0.00001045143,0.0003359173],"genre_scores_gemma":[0.9953621,0.0002853083,0.0002855413,0.00003194093,0.00002537046,0.00002802438,0.003565303,0.00001033059,0.0004060736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01528168,"threshold_uncertainty_score":0.03038543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01999356118560019,"score_gpt":0.3283903099142697,"score_spread":0.3083967487286695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}