{"id":"W4381432983","doi":"10.1186/s13058-023-01673-w","title":"Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium","year":2023,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Toronto; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Cancer Institute; NIHR Cambridge Biomedical Research Centre; Canadian Institutes of Health Research; Centre Léon Bérard; Manchester Biomedical Research Centre; Universitätsklinikum Köln; Direction Générale de l’offre de Soins; National Health and Medical Research Council; Institut National Du Cancer; Deutsche Krebshilfe; Cancer Research UK; KWF Kankerbestrijding; Fondation ARC pour la Recherche sur le Cancer; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Institut Gustave-Roussy; Vrije Universiteit Amsterdam; Erasmus Medisch Centrum; Universiteit Maastricht; Radboud Universiteit; Bundesministerium für Bildung und Forschung; Transcan; National Breast Cancer Foundation; Medical Research Council; Leids Universitair Medisch Centrum; Universiteit Leiden; Cancer Australia; Fondation de France; Radboud Universitair Medisch Centrum; Canadian Breast Cancer Research Alliance; Maastricht Universitair Medisch Centrum; Rijksuniversiteit Groningen; Amsterdam University Medical Centers; National Institute for Health and Care Research","keywords":"Surgical oncology; Breast cancer; Oncology; Medicine; Body mass index; Internal medicine; Cohort; Cancer; Gynecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001773252,0.0002096712,0.0003708538,0.0003350502,0.0001550152,0.00003587589,0.0003132361,0.0002123466,0.0001054823],"category_scores_gemma":[0.0001283778,0.000153133,0.00004861859,0.001457281,0.0007033005,0.00001740017,0.0002266569,0.0004378123,9.530683e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003299909,"about_ca_system_score_gemma":0.002180321,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01536382,"about_ca_topic_score_gemma":0.03195842,"domain_scores_codex":[0.9972171,0.0005262654,0.0004669238,0.0006220252,0.0005867192,0.0005810144],"domain_scores_gemma":[0.9985239,0.0001878845,0.0002139902,0.00048881,0.0004609455,0.0001245033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009672825,0.00006971171,0.9633486,0.00008719345,0.0003612039,0.00003445463,0.0006302433,0.001187593,0.02803619,0.00005945754,0.001039425,0.004178586],"study_design_scores_gemma":[0.001976711,0.00009796017,0.9914683,0.000132255,0.00005029069,0.00009882441,0.0008555022,0.001064867,0.003520425,0.0001244275,0.0004040634,0.0002063471],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912188,0.001932267,0.0000446695,0.00180896,0.00007396324,0.0008181263,0.003958868,0.000009160729,0.0001352009],"genre_scores_gemma":[0.9933398,0.005459917,0.00006596243,0.00004614443,0.0001151075,0.0005990033,0.0000608066,0.00004461507,0.0002686683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02811967,"threshold_uncertainty_score":0.9911929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01999356118560019,"score_gpt":0.3283903099142697,"score_spread":0.3083967487286695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}