{"id":"W4381469543","doi":"10.2478/raon-2023-0027","title":"Association between <i>PIK3CA</i> activating mutations and outcomes in early-stage invasive lobular breast carcinoma treated with adjuvant systemic therapy","year":2023,"lang":"en","type":"article","venue":"Radiology and Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Javna Agencija za Raziskovalno Dejavnost RS","keywords":"Medicine; Tamoxifen; Oncology; Internal medicine; Cohort; Invasive lobular carcinoma; Estrogen receptor; Proportional hazards model; Breast cancer; Systemic therapy; Stage (stratigraphy); Mutation; Invasive ductal carcinoma; Cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002915268,0.0001311255,0.0002483804,0.000307683,0.0001643195,0.0003191008,0.0001667615,0.0002516549,0.000926376],"category_scores_gemma":[0.0009467518,0.0001048481,0.0002313465,0.0003702372,0.0002140916,0.0001729409,0.0001670911,0.0003091387,0.00009903461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003137331,"about_ca_system_score_gemma":0.0002551521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001317838,"about_ca_topic_score_gemma":0.00226869,"domain_scores_codex":[0.9998707,0.00002724276,0.00001508151,0.00003541664,0.00002436544,0.00002716503],"domain_scores_gemma":[0.9990087,0.0002003372,0.0005171144,0.00003540967,0.00005811997,0.0001803622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005351273,0.00004059295,0.9975525,0.00000645167,0.00003659455,0.0001075057,0.00001205275,0.00006870823,0.0005560316,0.000003551359,0.00003510357,0.001045985],"study_design_scores_gemma":[0.00002715267,0.00025353,0.9986935,0.000002665883,0.0000409514,0.0005823716,0.00002954131,0.0001260839,0.000168982,0.000008082864,0.00006512717,0.000002086145],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997175,0.0001059693,0.0000199171,0.00001001173,0.000001037122,0.000002518138,0.00005048644,9.927247e-7,0.0000913637],"genre_scores_gemma":[0.9998229,0.00002742769,0.00001800087,0.000007624853,0.000003790123,0.000002192793,0.00008448621,4.927331e-7,0.00003295971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001317838,"threshold_uncertainty_score":0.003099024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01278233529977517,"score_gpt":0.2611999953768673,"score_spread":0.2484176600770921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}