{"id":"W4381469543","doi":"10.2478/raon-2023-0027","title":"Association between <i>PIK3CA</i> activating mutations and outcomes in early-stage invasive lobular breast carcinoma treated with adjuvant systemic therapy","year":2023,"lang":"en","type":"article","venue":"Radiology and Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Javna Agencija za Raziskovalno Dejavnost RS","keywords":"Medicine; Tamoxifen; Oncology; Internal medicine; Cohort; Invasive lobular carcinoma; Estrogen receptor; Proportional hazards model; Breast cancer; Systemic therapy; Stage (stratigraphy); Mutation; Invasive ductal carcinoma; Cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001805536,0.000174719,0.0004117342,0.0000934976,0.0001289501,0.000007526569,0.00005550269,0.0002738753,0.000002182014],"category_scores_gemma":[0.00005959144,0.0001377992,0.00002817137,0.000140428,0.0001340771,0.000007794369,0.00005272504,0.000115275,0.000002736412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001230832,"about_ca_system_score_gemma":0.00008671101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003797843,"about_ca_topic_score_gemma":0.0005199893,"domain_scores_codex":[0.9988914,0.0002313613,0.0001903004,0.0003512978,0.00005154089,0.0002841399],"domain_scores_gemma":[0.999319,0.0003210164,0.0001471292,0.0001143252,0.0000498798,0.00004866151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001579778,0.00002679537,0.9906666,0.00001238533,0.0004010187,0.00004009277,0.0005442865,0.00001882294,0.00563066,0.00001383684,0.00005256157,0.002434924],"study_design_scores_gemma":[0.00276496,0.0005903263,0.99369,0.00001363457,0.00005269218,0.0001514358,0.0005246399,0.000005673791,0.001819962,0.00002311609,0.0002238811,0.0001396513],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979206,0.0007277323,0.00001245567,0.0008099398,0.00003998155,0.0002707081,0.0001065675,0.00002549671,0.00008645799],"genre_scores_gemma":[0.9983554,0.0008877315,0.00004461793,0.0001209086,0.00007806488,0.0001144033,0.0002165173,0.00001637471,0.0001659889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003810698,"threshold_uncertainty_score":0.5619287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01278233529977517,"score_gpt":0.2611999953768673,"score_spread":0.2484176600770921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}