{"id":"W4381469699","doi":"10.1111/pan.14712","title":"Pharmacokinetic pharmacodynamic modeling of analgesics and sedatives in children","year":2023,"lang":"en","type":"review","venue":"Pediatric Anesthesia","topic":"Anesthesia and Sedative Agents","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Great Ormond Street Hospital Charity","keywords":"Pharmacodynamics; Pharmacokinetics; Medicine; Sedation; Analgesic; Dosing; Population; Sedative; Pharmacology; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001135764,0.001033167,0.001518802,0.001911581,0.0001555743,0.001064018,0.001008139,0.0008507274,0.002047395],"category_scores_gemma":[0.002230063,0.0003439388,0.001793753,0.001864435,0.0003339807,0.000999965,0.0004746678,0.001452409,0.00103421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007389343,"about_ca_system_score_gemma":0.001372248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002753773,"about_ca_topic_score_gemma":0.002389371,"domain_scores_codex":[0.9994792,0.0001426726,0.00008683889,0.00007008205,0.0001951657,0.00002596832],"domain_scores_gemma":[0.998969,0.00069386,0.0001546324,0.00002442796,0.0001434435,0.00001464222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001100052,0.00008432533,0.001115423,0.03659556,0.000534894,0.0003001671,0.00009408202,0.007869026,0.002250734,0.009295677,0.01376335,0.9279867],"study_design_scores_gemma":[0.00005397924,0.0004249519,0.005467259,0.0133259,0.001385207,0.004188241,0.0001317753,0.008044165,0.003875361,0.009639239,0.9533353,0.0001285407],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005094655,0.9944903,0.002789684,0.0003544352,0.0001063719,0.00002138203,0.0001373792,0.00003030626,0.001560751],"genre_scores_gemma":[0.003817134,0.9936739,0.001716639,0.0001247608,0.00009054701,0.00002924029,0.00009975514,0.000007535297,0.0004404137],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002753773,"threshold_uncertainty_score":0.006849229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06535735744448448,"score_gpt":0.3674656066835625,"score_spread":0.302108249239078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}