{"id":"W4381470336","doi":"10.1093/cid/ciad370","title":"Expanded Multivariable Models to Assist Patient Selection for Long-Acting Cabotegravir + Rilpivirine Treatment: Clinical Utility of a Combination of Patient, Drug Concentration, and Viral Factors Associated With Virologic Failure","year":2023,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada)","funders":"Janssen Pharmaceuticals; ViiV Healthcare","keywords":"Rilpivirine; Medicine; Internal medicine; Dosing; Regimen; Population; Body mass index; Post-hoc analysis; Quartile; Proportional hazards model; Viral load; Pharmacology; Human immunodeficiency virus (HIV); Confidence interval; Immunology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000328705,0.0002604775,0.0008325674,0.0000917075,0.0001621099,0.00001859649,0.00003621691,0.0001606884,0.00001852023],"category_scores_gemma":[0.001410658,0.000186714,0.0002425637,0.0004249852,0.0001839452,0.0001435187,0.00003532071,0.0001246484,0.000001495707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001303845,"about_ca_system_score_gemma":0.0002335823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008910531,"about_ca_topic_score_gemma":0.0002824025,"domain_scores_codex":[0.9976044,0.0002982955,0.001085308,0.000489221,0.0002494866,0.0002733034],"domain_scores_gemma":[0.9969137,0.001643305,0.000565545,0.000177403,0.0004220694,0.0002779423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006922376,0.004371337,0.9857262,0.00005419299,0.0006553635,0.000003263079,0.0005221087,0.0001337411,0.00002579851,0.00005002142,0.0002750609,0.007490706],"study_design_scores_gemma":[0.008770155,0.00526694,0.9733771,0.0001697422,0.0007934237,7.956298e-7,0.0003734755,0.009390494,0.001047701,0.0005333326,0.00007304419,0.0002037621],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967058,0.00003051668,0.0007589959,0.0001707696,0.000133095,0.001807775,0.0001735991,0.0001587792,0.00006063152],"genre_scores_gemma":[0.9987296,0.00003978055,0.00009182207,0.00004656184,0.00002886251,0.0001839626,0.0007206138,0.00002379148,0.0001349373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01234904,"threshold_uncertainty_score":0.7613975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06304437516076282,"score_gpt":0.349674355742804,"score_spread":0.2866299805820411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}