{"id":"W4381470336","doi":"10.1093/cid/ciad370","title":"Expanded Multivariable Models to Assist Patient Selection for Long-Acting Cabotegravir + Rilpivirine Treatment: Clinical Utility of a Combination of Patient, Drug Concentration, and Viral Factors Associated With Virologic Failure","year":2023,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada)","funders":"Janssen Pharmaceuticals; ViiV Healthcare","keywords":"Rilpivirine; Medicine; Internal medicine; Dosing; Regimen; Population; Body mass index; Post-hoc analysis; Quartile; Proportional hazards model; Viral load; Pharmacology; Human immunodeficiency virus (HIV); Confidence interval; Immunology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01315366,0.001423314,0.001556112,0.001060592,0.000460017,0.00137055,0.001431975,0.0004774784,0.006631155],"category_scores_gemma":[0.02306371,0.0005408425,0.002776579,0.0009135694,0.0001795954,0.0006266097,0.001408644,0.001967139,0.0006544783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005068659,"about_ca_system_score_gemma":0.002065557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009246374,"about_ca_topic_score_gemma":0.01110579,"domain_scores_codex":[0.9932922,0.005456613,0.0002132877,0.0004613908,0.0002861626,0.0002903502],"domain_scores_gemma":[0.9829577,0.01391072,0.0007826872,0.0007570991,0.001010062,0.0005817755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.009149506,0.0009581268,0.7077568,0.0003735384,0.01082086,0.0006407624,0.0007571315,0.08561235,0.001798437,0.001812967,0.01369826,0.1666213],"study_design_scores_gemma":[0.0006810877,0.001941546,0.08464329,0.0001059088,0.002449764,0.0003283765,0.0003943963,0.9007897,0.0007136526,0.003212339,0.004651599,0.00008819962],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8373792,0.00176898,0.1474908,0.00254046,0.0003818885,0.0005617248,0.005207245,0.002168514,0.002501072],"genre_scores_gemma":[0.9726095,0.0001564179,0.02402219,0.0001621978,0.0001158181,0.0001737601,0.001607144,0.0001252639,0.00102774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01315366,"threshold_uncertainty_score":0.06956404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06304437516076282,"score_gpt":0.349674355742804,"score_spread":0.2866299805820411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}