{"id":"W4381487478","doi":"10.1056/nejmoa2210054","title":"Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medizinische Universität Wien; Österreichische Forschungsförderungsgesellschaft; H2020 European Research Council; Centre National de la Recherche Scientifique; Universität Wien; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; ZonMw; Wellcome Trust; Agence Nationale de la Recherche; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst; Österreichischen Akademie der Wissenschaften; National Center for Geriatrics and Gerontology; Vienna Science and Technology Fund; Canadian Institutes of Health Research; Wellcome; European Molecular Biology Organization","keywords":"Biology; Immunology; Wiskott–Aldrich syndrome protein; Immune dysregulation; Wiskott–Aldrich syndrome; Haploinsufficiency; Cell biology; Proinflammatory cytokine; Immune system; Ectopic expression; Cancer research; Inflammation; Actin cytoskeleton; Phenotype; Genetics; Cytoskeleton; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001684906,0.00110776,0.0003354354,0.0007994015,0.0003199858,0.0003106671,0.0001778414,0.000461261,0.001159532],"category_scores_gemma":[0.0003402259,0.0002869203,0.0002259722,0.0003327606,0.0006042729,0.000164141,0.0004724433,0.0004183504,0.0001755565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002256839,"about_ca_system_score_gemma":0.0002045646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006405315,"about_ca_topic_score_gemma":0.001112288,"domain_scores_codex":[0.9997831,0.00004157779,0.0000305494,0.0000773232,0.00004345168,0.00002395859],"domain_scores_gemma":[0.9998103,0.00003362754,0.00008207376,0.00001178469,0.00001040754,0.00005182837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.001127605,0.0001157187,0.04726748,0.0001444502,0.00007509995,0.03687275,0.0003017548,0.0004491541,0.9089801,0.0004235019,0.0002307843,0.004011625],"study_design_scores_gemma":[0.0002646485,0.001627182,0.3796535,0.00009445236,0.0004743723,0.3403773,0.0004103751,0.003882996,0.2683955,0.0007218112,0.004022967,0.00007486919],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976733,0.0002938937,0.001296535,0.00003211926,0.000005708819,0.00001456845,0.0001311293,0.00005520772,0.0004975307],"genre_scores_gemma":[0.9982316,0.0001798594,0.001051022,0.00002602218,0.000005461441,0.00001070889,0.0001478203,0.00001091893,0.0003367033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001159532,"threshold_uncertainty_score":0.003878951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020752110462711,"score_gpt":0.2368443660152633,"score_spread":0.2266368449106362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}