{"id":"W4381487478","doi":"10.1056/nejmoa2210054","title":"Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medizinische Universität Wien; Österreichische Forschungsförderungsgesellschaft; H2020 European Research Council; Centre National de la Recherche Scientifique; Universität Wien; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; ZonMw; Wellcome Trust; Agence Nationale de la Recherche; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst; Österreichischen Akademie der Wissenschaften; National Center for Geriatrics and Gerontology; Vienna Science and Technology Fund; Canadian Institutes of Health Research; Wellcome; European Molecular Biology Organization","keywords":"Biology; Immunology; Wiskott–Aldrich syndrome protein; Immune dysregulation; Wiskott–Aldrich syndrome; Haploinsufficiency; Cell biology; Proinflammatory cytokine; Immune system; Ectopic expression; Cancer research; Inflammation; Actin cytoskeleton; Phenotype; Genetics; Cytoskeleton; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001124271,0.000107064,0.0003092753,0.0004137933,0.00006801331,0.00000535921,0.00013873,0.00009404028,0.00006825806],"category_scores_gemma":[0.0003553779,0.00007336397,0.00002870546,0.0003747939,0.000126083,0.0001096091,0.00002401941,0.0003229724,0.00004832221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000294013,"about_ca_system_score_gemma":0.00009411207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001266242,"about_ca_topic_score_gemma":0.000007240209,"domain_scores_codex":[0.9989495,0.0001128055,0.0005534287,0.00009550935,0.0000694705,0.0002192901],"domain_scores_gemma":[0.9993873,0.0002084231,0.0002354623,0.0000966639,0.00005952394,0.00001261932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005043285,0.00003430166,0.006566519,0.0001422809,0.00003950419,0.0001573231,0.01710037,0.0004762615,0.5781565,0.0009887973,0.001033364,0.3948004],"study_design_scores_gemma":[0.3310148,0.006065769,0.3996182,0.006469421,0.000536932,0.02732436,0.0277821,0.0004144335,0.02100135,0.007541611,0.17089,0.001340992],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613008,0.03543663,0.0000696213,0.001680461,0.0008158665,0.00007853239,5.702898e-7,0.00001816836,0.0005993356],"genre_scores_gemma":[0.9980635,0.001390148,0.000004478824,0.00004544467,0.00005876076,8.899064e-7,0.000009633231,0.000006480786,0.0004206506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5571552,"threshold_uncertainty_score":0.2991696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020752110462711,"score_gpt":0.2368443660152633,"score_spread":0.2266368449106362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}