{"id":"W4381487700","doi":"10.1200/jco.22.02555","title":"Severe Hepatopathy in National Wilms Tumor Studies 3-5: Prevalence, Clinical Features, and Outcomes After Reintroduction of Chemotherapy","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; University of Alberta Hospital; Alberta Hospital Edmonton","funders":"National Cancer Institute","keywords":"Medicine; Wilms' tumor; Chemotherapy; Incidence (geometry); Radiation therapy; Internal medicine; Demographics; Grading (engineering); Pediatrics; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008694548,0.0001727531,0.0002287403,0.0004387642,0.000368804,0.0004629218,0.0002799661,0.0002016536,0.0007564469],"category_scores_gemma":[0.002748492,0.0001104178,0.0002167887,0.0005664998,0.0003299394,0.0003235441,0.0005740692,0.0003129212,0.00006956574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000465499,"about_ca_system_score_gemma":0.0004198892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002635138,"about_ca_topic_score_gemma":0.004106564,"domain_scores_codex":[0.9994559,0.0001764882,0.00008246308,0.000089471,0.0001160117,0.00007973236],"domain_scores_gemma":[0.9974298,0.0004152108,0.00146608,0.0001183917,0.0001889814,0.0003815441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001008742,0.00001134799,0.9986871,0.00000394777,0.00001066452,0.0001039515,0.00002553715,0.0000234597,0.0001454023,0.000006423723,0.00004324811,0.0008380924],"study_design_scores_gemma":[0.00001370166,0.0001749417,0.9982483,0.000005403013,0.00001548702,0.001065368,0.00008425089,0.0001010552,0.0001473923,0.000009745264,0.0001325053,0.000001888755],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995658,0.0001282778,0.00002637836,0.00001526345,0.000001256369,0.000007348208,0.0001003549,0.000001817451,0.0001533939],"genre_scores_gemma":[0.9995185,0.00004505015,0.00003688634,0.00001054083,0.000003134953,0.000005668643,0.000349232,9.410026e-7,0.0000299778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002635138,"threshold_uncertainty_score":0.005239546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0472836705084622,"score_gpt":0.436726411250155,"score_spread":0.3894427407416928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}