{"id":"W4381490634","doi":"10.1016/j.bbamcr.2023.119520","title":"Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor","year":2023,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; Beatrice Hunter Cancer Research Institute","keywords":"Microphthalmia-associated transcription factor; Transactivation; Transcription factor; Regulator; Biology; Cell biology; IRF4; SOX10; Gene; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009016992,0.0002171975,0.0001836735,0.0001405062,0.000504259,0.0002553865,0.0004087476,0.0003516714,0.003055666],"category_scores_gemma":[0.0002275791,0.0001458624,0.0002993591,0.0001106822,0.0002768692,0.0001872469,0.0001770915,0.0006677101,0.001363606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008682557,"about_ca_system_score_gemma":0.0004917636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003145013,"about_ca_topic_score_gemma":0.003370089,"domain_scores_codex":[0.9999396,0.000006500747,0.000004123521,0.00001740241,0.00001603404,0.0000162573],"domain_scores_gemma":[0.9998877,0.00002754218,0.00001808901,0.00001022982,0.00001158267,0.00004486057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003879751,0.00002995991,0.0002573235,0.00005501839,0.000006173145,0.0002291349,0.00002769851,0.0002482609,0.9958593,0.001193946,0.0002022621,0.001502907],"study_design_scores_gemma":[0.0001062954,0.0001735418,0.01642712,0.00001788436,0.00001422522,0.0005796889,0.00006789307,0.006475472,0.969858,0.001189147,0.005064951,0.00002580452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833957,0.001929131,0.008474913,0.0006564902,0.00008974478,0.00006064686,0.0007961111,0.0002675334,0.004329785],"genre_scores_gemma":[0.9954792,0.0002636727,0.001759346,0.00007730856,0.00001507472,0.00002299824,0.0006722227,0.00001613536,0.001694004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003145013,"threshold_uncertainty_score":0.0102222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08964829051279126,"score_gpt":0.3649108201369782,"score_spread":0.275262529624187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}